Evidence map›Paper›PMID 38593125›Full record

ArticleeLife2024

Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.

Preksha Gaur, Yesheswini Rajendran, Bhagyashree Srivastava, Manasvini Markandey, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Aamir Suhail, Shikha Chaudhary, Shaifali Tyagi, Subhash Chandra Yadav and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Preksha GaurLaboratory of Gut Inflammation and Infection Biology, Regional Centre for Biotechnology, Faridabad, India.ORCID https://orcid.org/0000-0002-8011-1821
Yesheswini RajendranLaboratory of Gut Inflammation and Infection Biology, Regional Centre for Biotechnology, Faridabad, India.
Bhagyashree SrivastavaDepartmnet of Bioscience and Biotechnology, Banasthali Vidyapith, Aliyabad, India.
Manasvini MarkandeyDepartment of Gastroenterology, All India Institute of Medical Sciences, Delhi, India.
Vered Fishbain-YoskovitzDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Gayatree MohapatraDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Aamir SuhailGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, United States.
Shikha ChaudharyDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Shaifali TyagiVaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Faridabad, India.
Subhash Chandra YadavDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Amit Kumar PandeyVaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Faridabad, India.
Yifat MerblDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.
Avinash BajajLaboratory of Gut Inflammation and Infection Biology, Regional Centre for Biotechnology, Faridabad, India.ORCID https://orcid.org/0000-0002-1333-9316
Vineet AhujaDepartment of Gastroenterology, All India Institute of Medical Sciences, Delhi, India.
Chittur SrikanthLaboratory of Gut Inflammation and Infection Biology, Regional Centre for Biotechnology, Faridabad, India.ORCID https://orcid.org/0000-0001-9381-1213
All India Institute of Medical Sciences · INRegional Centre for Biotechnology · INWeizmann Institute of Science · ILTranslational Health Science and Technology Institute · INBanasthali University · INBrigham and Women's Hospital · US

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR45284/CMD/150/9/2022
6 · The paper itself

Abstract

Inflammation in ulcerative colitis is typically restricted to the mucosal layer of distal gut. Disrupted mucus barrier, coupled with microbial dysbiosis, has been reported to occur prior to the onset of inflammation. Here, we show the involvement of vesicular trafficking protein Rab7 in regulating the colonic mucus system. We identified a lowered Rab7 expression in goblet cells of colon during human and murine colitis. In vivo Rab7 knocked down mice (Rab7

Indexed as

ColitisGoblet CellsAnimalsChloride ChannelsColonDisease Models, AnimalHomeostasisHumansInflammationIntestinal MucosaMiceMice, Inbred C57BLrab7 GTP-Binding ProteinsChloride ChannelsCLCA1 protein, humanClca3a1 protein, mouserab7 GTP-Binding Proteinsrab7 GTP-binding proteins, humanrab7 GTP-binding proteins, mouseCLCA1goblet cellshumanimmunologyinflammationinflammatory bowel diseasemousemucusRab7 GTPaseulcerative colitis

Identifiers

PMID38593125
PMCPMC11003743
OpenAlexW4388125961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.