Evidence map›Paper›PMID 38593081›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.

Edit Szodorai, Zsofia Hevesi, Ludwig Wagner, Tomas G M Hökfelt, Tibor Harkany, Robert Schnell

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Edit SzodoraiDivision of Molecular and Cellular Neuroendocrinology, Department of Neuroscience, Biomedicum 7D, Karolinska Institutet, Solna SE-17165, Sweden.
Zsofia HevesiDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna A-1090, Austria.
Ludwig WagnerDepartment of Internal Medicine III, Medical University of Vienna, Vienna A-1090, Austria.
Tomas G M HökfeltDivision of Molecular and Cellular Neuroendocrinology, Department of Neuroscience, Biomedicum 7D, Karolinska Institutet, Solna SE-17165, Sweden.ORCID 0000-0002-3587-0116
Tibor Harkany *Division of Molecular and Cellular Neuroendocrinology, Department of Neuroscience, Biomedicum 7D, Karolinska Institutet, Solna SE-17165, Sweden.ORCID 0000-0002-6637-5900
Robert Schnell *Division of Molecular and Cellular Neuroendocrinology, Department of Neuroscience, Biomedicum 7D, Karolinska Institutet, Solna SE-17165, Sweden.
Karolinska Institutet · SEMedical University of Vienna · AT

Funding

Arvid Carlsson Fonden (Arvid Carlsson's Foundation) N/AEC | ERC | HORIZON EUROPE European Research Council (ERC) 2015-AdG-695136EC | ERC | HORIZON EUROPE European Research Council (ERC) 2020-AdG-101021016EC | ERC | HORIZON EUROPE European Research Council (ERC) 2022-PoC-101082277Hjärnfonden (Brain Foundation) FO2020-0178Novo Nordisk Fonden (NNF) NNF20OC0053667Vetenskapsrådet (VR) 2018-02838Vetenskapsrådet (VR) 2020-01688
6 · The paper itself

Abstract

Vesicular release of neurotransmitters and hormones relies on the dynamic assembly of the exocytosis/trans-SNARE complex through sequential interactions of synaptobrevins, syntaxins, and SNAP-25. Despite SNARE-mediated release being fundamental for intercellular communication in all excitable tissues, the role of auxiliary proteins modulating the import of reserve vesicles to the active zone, and thus, scaling repetitive exocytosis remains less explored. Secretagogin is a Ca

Indexed as

Membrane FusionSecretagoginsCell CommunicationCell MembraneExocytosisProtein BindingQa-SNARE ProteinsSynaptosomal-Associated Protein 25Syntaxin 1Qa-SNARE ProteinsSecretagoginsSynaptosomal-Associated Protein 25Syntaxin 1calciumstructural biologysynapsevesicular exocytosis

Identifiers

PMID38593081
PMCPMC11032447
OpenAlexW4394597702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.