ArticleProceedings of the National Academy of Sciences of the United States of America2024
Episymbiotic Saccharibacteria TM7x modulates the susceptibility of its host bacteria to phage infection and promotes their coexistence.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 29 citations in OpenAlex.
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- Ultrasmall oral Saccharibacteria modulate gingival immunoactivation through type IV pili and TLR2-dependent endocytosis.Nature communications · 2026Article
- Phase variation inEngineering microbiology · 2026Article
- Unveiling Global Diversity of Patescibacteriota and Functional Interactions with Host Microbes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Shuyu Wan Potentiates PD-1 Inhibitor Efficacy in Non-Small Cell Lung Cancer: Integrated Bioinformatics and Experimental Evidence for Gut Microbiota-Tumor Immune Crosstalk.Drug design, development and therapy · 2026Article
- Phage therapy of perinephric abscess in kidney transplantation recipients caused by drug-resistantmLife · 2025Article
- Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments.Nature communications · 2025Article
- Why Do FilamentousAnnual review of microbiology · 2025Review
- Identifying essential genes inJournal of bacteriology · 2025Article
- Stratified dietary inflammatory potential identifies oral and gut microbiota differences associated with cognitive function in older adults.Scientific reports · 2025Article
- The Subgingival Microbial Composition in Health and Periodontitis with Different Probing Depths.Microorganisms · 2025Article
- Candidate Phyla Radiation (CPR) bacteria from hyperalkaline ecosystems provide novel insight into their symbiotic lifestyle and ecological implications.Microbiome · 2025Article
- First-ever ASM Global Research Symposium on Microbes in Human Health in Tsinghua, Beijing, China.mSphere · 2025Article
- Mutations in Gordonia amarae mycolic acid biosynthetic pathway confer resistance to Patescibacteria parasite Mycosynbacter amalyticus.Nature communications · 2025Article
- Saccharibacteria deploy two distinct type IV pili, driving episymbiosis, host competition, and twitching motility.The ISME journal · 2025Article
- Beyond genomics in Patescibacteria: A trove of unexplored biology packed into ultrasmall bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
18 authors at 4 institutions in 2 countries.
Qiu Zhong *Department of Microbiology, College of Basic Medical Sciences, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Army Medical University, Chongqing 400038, China.
Binyou Liao *State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.ORCID 0000-0002-2622-1632
Jiazhen Liu *Department of Microbiology, College of Basic Medical Sciences, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Army Medical University, Chongqing 400038, China.
Wei ShenDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 401336, China.
Jing WangDepartment of Microbiology, College of Basic Medical Sciences, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Army Medical University, Chongqing 400038, China.
Leilei WeiDepartment of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing 400038, China.
Yansong MaDepartment of Orthodontics, Capital Medical University, Beijing 100050, China.
Pu-Ting DongDepartment of Microbiology, The American Dental Association Forsyth Institute, Cambridge, MA 02142.
Batbileg BorDepartment of Microbiology, The American Dental Association Forsyth Institute, Cambridge, MA 02142.
Jeffrey S McLeanDepartment of Periodontics, University of Washington, Seattle, WA 98119.ORCID 0000-0001-9934-5137
Yunjie ChangDepartment of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
Wenyuan ShiDepartment of Microbiology, The American Dental Association Forsyth Institute, Cambridge, MA 02142.
Lujia CenDepartment of Microbiology, The American Dental Association Forsyth Institute, Cambridge, MA 02142.
Miaomiao WuState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Jun LiuDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06536.ORCID 0000-0003-3108-6735
Yan LiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.ORCID 0000-0002-2323-8105
Xuesong HeDepartment of Microbiology, The American Dental Association Forsyth Institute, Cambridge, MA 02142.ORCID 0000-0002-3333-9188
Shuai LeDepartment of Microbiology, College of Basic Medical Sciences, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Army Medical University, Chongqing 400038, China.ORCID 0000-0003-3748-5454
Army Medical University · CNAmerican Dental Association · USSichuan University · CNUniversity of Washington · US
Funding
Structure-Function Relationships in the Spirochetal Flagellar MotorR01AI087946 · NIAID · YALE UNIVERSITY · PI LIU, JUN · 2010 to 2025
$6.6MDomestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6MDelineation of unique flagellar proteins in spirochetesR01AI132818 · NIAID · EAST CAROLINA UNIVERSITY · PI Jun Liu, MD A MOTALEB · 2018 to 2026
$3.3MStructural basis of phage infection and DNA ejectionR01GM110243 · NIGMS · YALE UNIVERSITY · PI LIU, JUN, MOLINEUX, IAN J · 2014 to 2024
$3.1MFunctional and Structural Analysis of the Dot/Icm Type IVB Secretion MachineR01AI152421 · NIAID · YALE UNIVERSITY · PI LIU, JUN, ROY, CRAIG R. · 2020 to 2024
$2.9MImpact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory DiseasesR01DE031274 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Batbileg Bor · 2022 to 2026
$2.5MHost tRNA-derived small RNAs (tsRNAs) mediate interactions between host and oral microbesR01DE030943 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI Xuesong He · 2022 to 2026
$2.4MHigh-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9MInitiation of Phage InfectionR01GM124378 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MOLINEUX, IAN J · 2017 to 2020
$1.3MNIAID NIH HHS R01 AI087946NIAID NIH HHS R01 AI132818NIAID NIH HHS R01 AI152421NIDCR NIH HHS R01 DE023810NIDCR NIH HHS R01 DE030943NIDCR NIH HHS R01 DE031274NIGMS NIH HHS R01 GM110243NIGMS NIH HHS R01 GM124378NIH HHS S10 OD023603
Abstract
Bacteriophages (phages) play critical roles in modulating microbial ecology. Within the human microbiome, the factors influencing the long-term coexistence of phages and bacteria remain poorly investigated. Saccharibacteria (formerly TM7) are ubiquitous members of the human oral microbiome. These ultrasmall bacteria form episymbiotic relationships with their host bacteria and impact their physiology. Here, we showed that during surface-associated growth, a human oral Saccharibacteria isolate (named TM7x) protects its host bacterium, a
Indexed as
BacteriophagesBacteriaHumansSymbiosisbacteria-phage interactionepisymbiosisphage resistanceSaccharibacteriaTM7x
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