Evidence map›Paper›PMID 38593077›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Engineering a nanoantibiotic system displaying dual mechanism of action.

Huihua Xing, Luana Janaína de Campos, Aramis Jose Pereira, Maria Mercedes Fiora, Fabio Aguiar-Alves, Mario Tagliazucchi, Martin Conda-Sheridan

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Huihua Xing *Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198.ORCID 0000-0001-7276-6601
Luana Janaína de Campos *Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198.ORCID 0000-0001-8527-688X
Aramis Jose PereiraDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198.
Maria Mercedes FioraInstituto Nacional de Tecnología Industrial, Micro y Nanotecnologías, San Martín, Buenos Aires B1650WAB, Argentina.
Fabio Aguiar-AlvesDepartment of Pharmaceutical Sciences, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, FL 33401.
Mario TagliazucchiUniversidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Inorgánica Analítica y Química Física, Pabellón 2, Ciudad Universitaria, Ciudad Autónoma de Buenos Aires C1428, Argentina.ORCID 0000-0003-4755-955X
Martin Conda-SheridanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198.ORCID 0000-0002-3568-2545
Nebraska Medical Center · USConsejo Nacional de Investigaciones Científicas y Técnicas · ARPalm Beach Atlantic University · US

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) ANPCyT PICT 1520-2019National Science Foundation (NSF) DMR-1941731US-Egypt Joint Board on Scientific and Technological Cooperation (U.S. - Egypt Joint Board) 72026321CA00001
6 · The paper itself

Abstract

In recent decades, peptide amphiphiles (PAs) have established themselves as promising self-assembling bioinspired materials in a wide range of medical fields. Herein, we report a dual-therapeutic system constituted by an antimicrobial PA and a cylindrical protease inhibitor (LJC) to achieve broad antimicrobial spectrum and to enhance therapeutic efficacy. We studied two strategies: PA-LJC nanostructures (

Indexed as

Anti-Infective AgentsNanostructuresAnti-Bacterial AgentsGram-Negative BacteriaGram-Positive BacteriaAnti-Bacterial AgentsAnti-Infective Agentsantimicrobialdual therapynanostructurespeptide amphiphiles

Identifiers

PMID38593077
PMCPMC11032466
OpenAlexW4394597605

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.