ArticleThe Plant cell2024
The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 28 citations in OpenAlex.
- Genome-Wide Identification of theGenes · 2026Article
- NUDX gene family identification and its potential role in carotenoid biosynthesis of carrot.Biotechnology letters · 2026Article
- DcGATA22 serves as a transcription factor positively coordinating chlorophyll and carotenoid accumulation in carrot.Planta · 2026Article
- DcLcyB1 and DcLcyB2, two lycopene β-cyclases with partial functional overlap modulate carotene profiles in carrot roots via distinct catalytic properties.Molecular horticulture · 2026Article
- Genome-wide identification and promoter activity analysis of fibrillin gene families in different color carrot roots.Protoplasma · 2026Article
- Different Distribution of Carotenoid Content in Periderm-Phloem-Xylem of Red Carrot Taproots.Molecular biotechnology · 2026Article
- The combined effects of Golden2-like 2 and Pseudo-Response Regulator 2 control the fruit pigmentation in pepper.The Plant journal : for cell and molecular biology · 2026Article
- Effects of three light-dark cycles on circadian rhythm-related genes and photosynthetic parameters in carrot.Biotechnology letters · 2026Article
- Analysis of telomere-to-telomere genome of red carrot TXH4 elucidates the role of DcLCYE and DcLCYB1 in lycopene accumulation in carrot.Horticulture research · 2025Article
- Editing of rice PSEUDO-ETIOLATION IN LIGHT microProtein genes promotes chloroplast development.The Plant cell · 2025Article
- Physiological and transcriptomic analyses reveal the mechanisms underlying leaf color variation in zebra-striped mutants of oat (Avena sativa).BMC plant biology · 2025Article
- A melon (bioRxiv : the preprint server for biology · 2025Article
- Dark-responsive BGH2 and light-responsive BPG4: Taming the GLK1/2 master transcription factors for etioplast and chloroplast homeostasis.The Plant cell · 2025Article
- The KNOX transcription factor ClSP activates ClAPRR2 to regulate dark green stripe formation in watermelon.Plant biotechnology journal · 2025Article
- Carotene hydroxylase DcCYP97A3 affects carotenoid metabolic flow and taproot color by influencing the conversion of α-carotene to lutein in carrot.Horticulture research · 2025Article
- Combining genome-wide association and genomic prediction to unravel the genetic architecture of carotenoid accumulation in carrot.The plant genome · 2025Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
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Abstract
Little is known about the factors regulating carotenoid biosynthesis in roots. In this study, we characterized DCAR_032551, the candidate gene of the Y locus responsible for the transition of root color from ancestral white to yellow during carrot (Daucus carota) domestication. We show that DCAR_032551 encodes a REPRESSOR OF PHOTOSYNTHETIC GENES (RPGE) protein, named DcRPGE1. DcRPGE1 from wild carrot (DcRPGE1W) is a repressor of carotenoid biosynthesis. Specifically, DcRPGE1W physically interacts with DcAPRR2, an ARABIDOPSIS PSEUDO-RESPONSE REGULATOR2 (APRR2)-like transcription factor. Through this interaction, DcRPGE1W suppresses DcAPRR2-mediated transcriptional activation of the key carotenogenic genes phytoene synthase 1 (DcPSY1), DcPSY2, and lycopene ε-cyclase (DcLCYE), which strongly decreases carotenoid biosynthesis. We also demonstrate that the DcRPGE1W-DcAPRR2 interaction prevents DcAPRR2 from binding to the RGATTY elements in the promoter regions of DcPSY1, DcPSY2, and DcLCYE. Additionally, we identified a mutation in the DcRPGE1 coding region of yellow and orange carrots that leads to the generation of alternatively spliced transcripts encoding truncated DcRPGE1 proteins unable to interact with DcAPRR2, thereby failing to suppress carotenoid biosynthesis. These findings provide insights into the transcriptional regulation of carotenoid biosynthesis and offer potential target genes for enhancing carotenoid accumulation in crop plants.
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