ArticleThe Plant cell2024
The phytochrome-interacting factor genes PIF1 and PIF4 are functionally diversified due to divergence of promoters and proteins.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- CML20 integrates phytochrome and calcium signaling pathways to optimize seed germination under abiotic stress.Nature communications · 2026Article
- Oligomerization-competent PIF4 drives thermomorphogenesis through functional redundancy in transactivation and DNA binding.Nature communications · 2026Article
- Transcriptome profiling reveals divergent response strategies in two olive cultivars with contrasting drought tolerance.Plant physiology · 2026Article
- A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins.Nature plants · 2026Article
- Light intensity affects growth, photosynthesis and nutritional properties of Toona sinensis sprouts in plant factory.Photosynthesis research · 2025Article
- PIF4-mediated thermomorphogenesis relies on its oligomerization ability, not DNA-binding or transactivation activity.Research square · 2025Article
- OsbHLH062 regulates iron homeostasis by inhibiting iron deficiency responses in rice.aBIOTECH · 2025Article
- Species-specific PHYTOCHROME-INTERACTING FACTOR utilization in the plant morphogenetic response to environmental stimuli.The Plant cell · 2025Article
- Shedding light on shade-avoidance: SlPIF8a plays a pivotal role in the tomato shade response.The Plant cell · 2025Article
- Using chimeric rice proteins to make heads or tails of the function of repetitive elements in Gγ subunits.The Plant cell · 2025Article
- The PEAPOD repressor complex in Arabidopsis stomatal development.Frontiers in plant science · 2025Review
- Specific binding between Arabidopsis thaliana phytochrome-interacting factor 3 (AtPIF3) bHLH and G-box originated prior to embryophyte emergence.BMC plant biology · 2024Article
- Evolution and Domestication of a Novel Biosynthetic Gene Cluster Contributing to the Flavonoid Metabolism and High-Altitude Adaptability of Plants in the Fagopyrum Genus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Branching paths: Unveiling functional divergence of PIF1 and PIF4 via promoter and protein variations.The Plant cell · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Phytochrome-interacting factors (PIFs) are basic helix-loop-helix transcription factors that regulate light responses downstream of phytochromes. In Arabidopsis (Arabidopsis thaliana), 8 PIFs (PIF1-8) regulate light responses, either redundantly or distinctively. Distinctive roles of PIFs may be attributed to differences in mRNA expression patterns governed by promoters or variations in molecular activities of proteins. However, elements responsible for the functional diversification of PIFs have yet to be determined. Here, we investigated the role of promoters and proteins in the functional diversification of PIF1 and PIF4 by analyzing transgenic lines expressing promoter-swapped PIF1 and PIF4, as well as chimeric PIF1 and PIF4 proteins. For seed germination, PIF1 promoter played a major role, conferring dominance to PIF1 gene with a minor contribution from PIF1 protein. Conversely, for hypocotyl elongation under red light, PIF4 protein was the major element conferring dominance to PIF4 gene with the minor contribution from PIF4 promoter. In contrast, both PIF4 promoter and PIF4 protein were required for the dominant role of PIF4 in promoting hypocotyl elongation at high ambient temperatures. Together, our results support that the functional diversification of PIF1 and PIF4 genes resulted from contributions of both promoters and proteins, with their relative importance varying depending on specific light responses.
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