Evidence map›Paper›PMID 38592769›Full record

ArticlePlants (Basel, Switzerland)2024

Valentina Laghezza Masci, Enrica Alicandri, Chiara Antonelli, Anna Rita Paolacci, Rosita Marabottini, William Tomassi, Giuseppe Scarascia Mugnozza, Antonio Tiezzi, Stefania Garzoli, Vittorio Vinciguerra and 3 more

Open access · goldAbstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Quality by Design-Guided Development ofMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Essential Oils ofPathogens (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Article
  6. A Phytochemical and Biological Characterization ofMolecules (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Valentina Laghezza MasciDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0002-7680-7404
Enrica AlicandriDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0003-0296-1940
Chiara AntonelliDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0002-1430-3235
Anna Rita PaolacciDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.
Rosita MarabottiniDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0003-3030-7735
William TomassiDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0009-0008-6986-6650
Giuseppe Scarascia MugnozzaDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0003-0357-4360
Antonio TiezziDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.
Stefania GarzoliDepartment of Drug Chemistry and Technology, Sapienza University, 00185 Rome, Italy.ORCID 0000-0001-8535-0533
Vittorio VinciguerraDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0003-1037-3567
Anna Maria VettrainoDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0003-0797-3297
Elisa OvidiDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0001-8876-6331
Mario CiaffiDepartment for the Innovation in Biological, Agrofood and Forestal Systems, Tuscia University, 01100 Viterbo, Italy.ORCID 0000-0001-5335-1371
Università degli Studi della Tuscia · ITSapienza University of Rome · IT

Funding

Lazio Innova-Ricerca e Innovazione del POR FESR Lazio 2014-2020 "Progetti di Gruppi di Ricerca" CUP J85F21000410002
6 · The paper itself

Abstract

The preservation of agricultural biodiversity and socioeconomic development are relevant both to enhance domestic production and to support innovation. In the search for new biomolecules, we have focused on the "Carciofo Ortano" landrace, growth in the northern part of the Lazio region. Artichoke cultivation generates substantial by-products, including leaves, stems, and roots, which could serve as valuable sources of biomolecules and prebiotic dietary fiber. To valorize the leaf waste of the "Carciofo Ortano" landrace, a multidisciplinary approach was applied. Chemical analysis using HPLC-DAD identified mono-O- and di-O-caffeoylquinic acids and the sesquiterpene cynaropicrin in all artichoke leaf extracts. SPME-GC/MS analyses detected aliphatic alcohols in the fresh leaf samples. Antiproliferative and cytotoxic studies on cancer (SH-SY5Y, MCF-7, MDA) and normal (MCF-10A) human cell lines revealed that leaf extracts induced a selective dose and time-dependent biological effect. While showing slight activity against environmental bacterial strains, artichoke leaf extracts exhibited significant antifungal activity against the phytopathogenic fungus

Indexed as

Alternaria alternataartichoke leaf extractsartichoke waste“Carciofo Ortano” landraceCynara cardunculus L. var. scolymuscytotoxicityphenolic compositionsecondary metabolitesvolatile organic compounds (VOCs)

Identifiers

PMID38592769
PMCPMC10976138
OpenAlexW4392546016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.