Evidence map›Paper›PMID 38592581›Full record

ArticleNeuroscience bulletin2024

Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury.

Jiezhao Lin, Yuanfang Sun, Bin Xia, Yihan Wang, Changnan Xie, Jinfeng Wang, Jinwei Hu, Lixin Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiezhao Lin *Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.ORCID http://orcid.org/0000-0002-6576-6846
Yuanfang Sun *Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.ORCID http://orcid.org/0009-0000-8909-1743
Bin Xia *Department of Orthopedics, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, 610299, China.ORCID http://orcid.org/0009-0002-0810-1095
Yihan WangDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.ORCID http://orcid.org/0000-0001-5181-6702
Changnan XieDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.ORCID http://orcid.org/0000-0003-3932-1007
Jinfeng WangDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.ORCID http://orcid.org/0009-0001-4012-3633
Jinwei HuDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.ORCID http://orcid.org/0009-0000-7857-2939
Lixin ZhuDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. zhulixin1966@163.com.ORCID http://orcid.org/0000-0003-3055-3063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of the blood-spinal cord barrier (BSCB) is a critical event in the secondary injury following spinal cord injury (SCI). Mertk has been reported to play an important role in regulating inflammation and cytoskeletal dynamics. However, the specific involvement of Mertk in BSCB remains elusive. Here, we demonstrated a distinct role of Mertk in the repair of BSCB. Mertk expression is decreased in endothelial cells following SCI. Overexpression of Mertk upregulated tight junction proteins (TJs), reducing BSCB permeability and subsequently inhibiting inflammation and apoptosis. Ultimately, this led to enhanced neural regeneration and functional recovery. Further experiments revealed that the RhoA/Rock1/P-MLC pathway plays a key role in the effects of Mertk. These findings highlight the role of Mertk in promoting SCI recovery through its ability to mitigate BSCB permeability and may provide potential targets for SCI repair.

Indexed as

c-Mer Tyrosine KinaserhoA GTP-Binding Proteinrho-Associated KinasesSpinal CordSpinal Cord InjuriesAnimalsEndothelial CellsRatsRats, Sprague-Dawleyrho GTP-Binding ProteinsSignal Transductionc-Mer Tyrosine KinaserhoA GTP-Binding ProteinRhoA protein, ratrho-Associated Kinasesrho GTP-Binding ProteinsApoptosisBlood-spinal cord barrierInflammationMertkRhoA/Rock1/P-MLC pathwaySpinal cord injury

Identifiers

PMID38592581
PMCPMC11365875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.