Evidence map›Paper›PMID 38592520›Full record

ArticleEuropean journal of nutrition2024

Lacticaseibacillus casei K11 exerts immunomodulatory effects by enhancing natural killer cell cytotoxicity via the extracellular regulated-protein kinase pathway.

Yu Zhou, Malina Kuerman, Qi Zhou, Baochao Hou, Baolei Li, Yang Li, Lanwei Zhang, Tongjie Liu

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Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu Zhou *College of Food Science and Engineering, Ocean University of China, N-O-1299 Sansha Road, Qingdao, 266003, China.
Malina Kuerman *College of Food Science and Engineering, Ocean University of China, N-O-1299 Sansha Road, Qingdao, 266003, China.
Qi ZhouCollege of Food Science and Engineering, Ocean University of China, N-O-1299 Sansha Road, Qingdao, 266003, China.
Baochao HouNational Center of Technology Innovation for Dairy, Hohhot, 010000, China.
Baolei LiNational Center of Technology Innovation for Dairy, Hohhot, 010000, China.
Yang LiCollege of Food Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China.
Lanwei ZhangCollege of Food Science and Engineering, Ocean University of China, N-O-1299 Sansha Road, Qingdao, 266003, China. zhanglanwei@ouc.edu.cn.ORCID http://orcid.org/0000-0003-3459-2975
Tongjie LiuCollege of Food Science and Engineering, Ocean University of China, N-O-1299 Sansha Road, Qingdao, 266003, China. liutongjie@ouc.edu.cn.

Funding

National Center of Technology Innovation for Dairy 2021-Open Project-6National Natural Science Foundation of China 32201985Natural Science Foundation of Shandong Province ZR2020QC240the National Natural Science Foundation of China 31972051the Project of Taishan Industry Leading Talent of Shandong Province LJNY202101
6 · The paper itself

Abstract

purposeProbiotics can serve as immunomodulators that regulate the activation of immune cells. This study aimed to screen potential probiotic strains that can enhance NK cell toxicity to improve host immunity.

methodsIn this investigation, we examined three potential probiotic strains, namely Lactiplantibacillus plantarum YZX21 (YZX21), Bifidobacterium bifidum FL-276.1 (FL-276.1) and Lacticaseibacillus casei K11 (K11), to assess their capacity in modulating NK cytotoxicity both in vitro and in vivo, while elucidating the underlying mechanisms involved.

resultsThe findings demonstrated that K11 exhibited superior efficacy in enhancing NK cytotoxicity. Subsequent analysis revealed that K11 significantly augmented the secretion of perforin and granzyme B by NK cells through activation of receptors NKp30 and NKp46 via the extracellular signal-regulated kinase (ERK) pathway. Furthermore, heat-inactivated K11 also enhanced NK cell activity to an extent comparable to live bacteria, with lipoteichoic acid from K11 identified as a crucial factor mediating the activation of NK cell cytotoxicity.

conclusionOur study suggests that K11 may have potential applications as probiotics or postbiotics for regulating NK cell cytotoxicity to enhance immunity.

Indexed as

Killer Cells, NaturalLacticaseibacillus caseiProbioticsAnimalsExtracellular Signal-Regulated MAP KinasesHumansImmunomodulating AgentsMAP Kinase Signaling SystemMiceExtracellular Signal-Regulated MAP KinasesImmunomodulating AgentsERK pathwayImmunoregulationLipoteichoic acidNK cell cytotoxicityProbiotics

Identifiers

PMID38592520

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.