ArticleEuropean heart journal2024
Atrial fibrillation: age at diagnosis, incident cardiovascular events, and mortality.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Freely available genomic datasets for atrial fibrillation research: current resources and analytical pipeline.Frontiers in genetics · 2026Pooled it
- Persistent atrial fibrillation with left atrial low-voltage area: who benefit from additional modification?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Trial
- Accumulation of chronic conditions in patients aged <65 years diagnosed with atrial fibrillation.Heart rhythm · 2026Article
- Article
- Comprehensive Analysis of Atrial Fibrillation/Atrial Flutter Burden in the United States and the European Union: A Comparison and Assessment of Trends and Risk Factors.Journal of cardiovascular development and disease · 2026Article
- Prevalence of deleterious variants in cardiomyopathy genes in early-onset atrial fibrillation.European journal of human genetics : EJHG · 2026Article
- Left atrial strain compared to volume in long-term flecainide treated patients with atrial fibrillation - a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Genetic evaluation of early-onset atrial fibrillation: impact on patient management.European heart journal · 2026Article
- Global burden of atrial fibrillation/atrial flutter and its attributable risk factors in adolescents and young adults, 1990-2021: insights from the global burden of disease study.Annals of medicine · 2025Article
- Atrial Fibrillation at Hassan II Regional Hospital, Agadir, Morocco: Insights Into Presentation and Management.Cureus · 2025Article
- Prevalence of deleterious variants in cardiomyopathy genes in early-onset atrial fibrillation.Research square · 2025Article
- Development and validation of a predictive model for survival outcomes in patients with paroxysmal versus persistent atrial fibrillation: a retrospective cohort study based on the MIMIC-IV database.BMC cardiovascular disorders · 2025Article
- Vascular cell adhesion molecule 1: a marker for atrial fibrillation and heart failure risk.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Molecular mechanisms and intervention approaches of heart failure (Review).International journal of molecular medicine · 2025Review
- From moderate to strenuous training: unravelling mechanistic contributors and biomarkers for atrial fibrillation in exercise.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Polygenic Risk and Cardiovascular Event Risk in Patients With Atrial Fibrillation With Low to Intermediate Stroke Risk.Journal of the American Heart Association · 2025Article
- Atrial fibrillation in Black American patients: A review of genetics, risk factors, and outcomes.Heart rhythm · 2025Review
- Association Between Age at Diagnosis of Atrial Fibrillation and Subsequent Risk of Ischemic Stroke.Journal of the American Heart Association · 2025Article
- Global, regional, and national burden of atrial fibrillation and flutter associated with metabolic risk factors, 1990-2021.Frontiers in cardiovascular medicine · 2025Article
- Real-World Comparative Study of Ultra-Low-Dose Rivaroxaban in Very Elderly Patients with Atrial Fibrillation.Clinical interventions in aging · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND AND
aimsPatients with atrial fibrillation (AF) are at increased risks of cardiovascular diseases and mortality, but risks according to age at diagnosis have not been reported. This study investigated age-specific risks of outcomes among patients with AF and the background population.
methodsThis nationwide population-based cohort study included patients with AF and controls without outcomes by the application of exposure density matching on the basis of sex, year of birth, and index date. The absolute risks and hazard rates were stratified by age groups and assessed using competing risk survival analyses and Cox regression models, respectively. The expected differences in residual life years among participants were estimated.
resultsThe study included 216 579 AF patients from year 2000 to 2020 and 866 316 controls. The mean follow-up time was 7.9 years. Comparing AF patients with matched controls, the hazard ratios among individuals ≤50 years was 8.90 [95% confidence interval (CI), 7.17-11.0] for cardiomyopathy, 8.64 (95% CI, 7.74-9.64) for heart failure, 2.18 (95% CI, 1.89-2.52) for ischaemic stroke, and 2.74 (95% CI, 2.53-2.96) for mortality. The expected average loss of life years among individuals ≤50 years was 9.2 years (95% CI, 9.0-9.3) years. The estimates decreased with older age.
conclusionsThe findings show that earlier diagnosis of AF is associated with a higher hazard ratio of subsequent myocardial disease and shorter life expectancy. Further studies are needed to determine causality and whether AF could be used as a risk marker among particularly younger patients.
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