Evidence map›Paper›PMID 38592188›Full record

ArticleJournal of clinical medicine2024

Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer.

Vaia Lambadiari, Aikaterini Kountouri, Fοteini Psahoulia, Georgia-Angeliki Koliou, Andreas Lazaris, Efstathios Michalopoulos, Panagiotis Mallis, Emmanouil Korakas, Ioanna Eleftheriadou, Konstantinos Balampanis and 6 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Cord Blood-Derived Platelet Gel in Wound Healing: From Biological Rationale to Clinical Application.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Vaia LambadiariSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Aikaterini KountouriSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0001-5829-7327
Fοteini PsahouliaDepartment of Vascular Surgery, Attikon University Hospital, 12462 Athens, Greece.
Georgia-Angeliki KoliouSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Andreas LazarisDepartment of Vascular Surgery, Attikon University Hospital, 12462 Athens, Greece.
Efstathios MichalopoulosHellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.ORCID 0000-0002-1901-6294
Panagiotis MallisHellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.ORCID 0000-0001-9429-190X
Emmanouil KorakasSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-7813-5488
Ioanna EleftheriadouFirst Department of Propaedeutic Internal Medicine, Diabetes Centre, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Konstantinos BalampanisSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Markos SarrisHealth and Social Care Management, University of West Attica, 12241 Athens, Greece.
Panagiotis TsirigotisSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
George GeroulakosDepartment of Vascular Surgery, Attikon University Hospital, 12462 Athens, Greece.
Catherine Stavropoulos-GiokasHellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.
George D DimitriadisSector of Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-0315-9936
Nikolaos TentolourisFirst Department of Propaedeutic Internal Medicine, Diabetes Centre, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Funding

European Union T1EDK-05722
6 · The paper itself

Abstract

backgroundThis study was conducted to examine the hypothesis that umbilical cord blood platelet lysate (UCB-PL) gel has a significant impact on the healing rate of DFU. Μethods: In this open-labeled, randomized controlled trial, 110 patients were randomized to treatment with UCB-PL gel (UCB-PL group, n = 52) every three days for one month or dressing with normal saline (control group, n = 58). All participants were followed up for 20 weeks post treatment. Ulcer surface area was assessed with the imitoMeasure application at two, four, and six weeks, and two, four and six months. This study's main outcome was the reduction in ulcer size over the six-month study period.

resultsThe mean ulcer area at baseline was 4.1 cm

conclusionsThe application of UCB-PL gel in DFU resulted in a significant reduction in ulcer size compared to regular saline dressing.

Indexed as

diabetic footdiabetic foot treatmentplatelet lysateplatelet rich plasmaumbilical cord blood

Identifiers

PMID38592188
PMCPMC10932121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.