Evidence map›Paper›PMID 38592182›Full record

ReviewJournal of clinical medicine2024

The Role of Tau Pathology in Alzheimer's Disease and Down Syndrome.

Ann-Charlotte Granholm, Eric D Hamlett

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Blood-based biomarkers for Alzheimer's disease in Down syndrome: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Vertebrate and Invertebrate Animal Models for the Study of Down Syndrome.International journal of molecular sciences · 2025
    Review
  12. Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ann-Charlotte GranholmDepartment of Neurosurgery, University of Colorado Anschutz Medical Center, Aurora, CO 80045, USA.ORCID 0000-0002-9685-7599
Eric D HamlettDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-2900-7949

Funding

Tau pathology in Down syndrome and Alzheimer'sRF1AG061566 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, MARGITTAI, MARTIN · 2019 to 2019
$3.4M
Exosome biology in Alzheimer's disease and concussion.R01AG071228 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER, LEDREUX, AURELIE · 2021 to 2025
$3.1M
Noradrenergic dysfunction in Down SyndromeRF1AG070153 · NIA · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI LEDREUX, AURÉLIE · 2020 to 2020
$1.8M
NIA NIH HHS R01 AG071228NIA NIH HHS RF1 AG061566NIA NIH HHS RF1 AG070153NIH HHS R01AG071228-02, R01AG070153, and R01AG061566
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer’s disease (AD)Down syndrome (DS)neurofibrillary tangles (NFTs)neuropathologyseeding competent p-Tau

Identifiers

PMID38592182
PMCPMC10932364

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.