Evidence map›Paper›PMID 38591917›Full record

ArticleMicrobiology spectrum2024

Tetracyclic homoisoflavanoid (+)-brazilin: a natural product inhibits c-di-AMP-producing enzyme and

Edwin M Rojas, Hua Zhang, Sadanandan E Velu, Hui Wu

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in microbiology · 2025
    Article
  4. TiORSC advances · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Edwin M RojasSchool of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Hua ZhangDivision of Biomaterial & Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA.
Sadanandan E VeluDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-0342-2378
Hui WuDivision of Biomaterial & Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0003-1694-3954
Oregon Health & Science University · USUniversity of Alabama at Birmingham · US

Funding

Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
PORT (Portland Oral health Research Training)T90DE030859 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI WU, HUI · 2021 to 2025
$2.1M
BACTERIAL SECOND MESSENGER MEDIATED VIRULENCE REGULATION IN STREPTOCOCCUS MUTANSR01DE028329 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2019 to 2023
$1.7M
Hydrogel encapsulated biofilm inhibitors for dental caries prevention and treatmentR21DE028349 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VELU, SADANANDAN E. · 2019 to 2020
$396k
S. mutans GTF - a novel target for dental caries preventionR03DE025058 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VELU, SADANANDAN E. · 2015 to 2016
$221k
Streptococcus mutans diadenylate cyclase: A promising target for preventing dental cariesF30DE030334 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROJAS, EDWIN M · 2020 to 2024
$212k
NIDCR NIH HHS F30 DE030334NIDCR NIH HHS R01 DE022350NIDCR NIH HHS R01 DE028329NIDCR NIH HHS R03 DE025058NIDCR NIH HHS R21 DE028349NIDCR NIH HHS T90 DE022736NIDCR NIH HHS T90 DE030859
6 · The paper itself

Abstract

The tenacious biofilms formed by

Indexed as

Anti-Bacterial AgentsBiofilmsIsoflavonesStreptococcus mutansBacterial ProteinsBiological ProductsHumansMicrobial Sensitivity TestsPhosphorus-Oxygen LyasesAnti-Bacterial AgentsBacterial ProteinsBiological ProductsIsoflavonesPhosphorus-Oxygen Lyasesbiofilm inhibition(+)-brazilincyclic di-AMPdental cariesdiadenylate cyclasenatural productsStreptococcus mutans

Identifiers

PMID38591917
PMCPMC11064632
OpenAlexW4394605662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.