ArticleRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia2024
Azithromycin and moxifloxacin resistance determinants in Mycoplasma genitalium in Lleida, Spain.
Article in Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Drug resistance ofFrontiers in cellular and infection microbiology · 2026Review
- Performance of Allplex™ MG & AziR Assay for Detecting Macrolide-ResistantJournal of Korean medical science · 2025Article
- AutomatedMicrobiology spectrum · 2025Article
- Article
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11 authors.
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Abstract
objectiveMycoplasma genitalium (MG) is a microorganism related to sexually transmitted infections. Antibiotic resistance of MG leads to an increase in treatment failure rates and the persistence of the infection. The aim of this study was to describe the most frequent mutations associated with azithromycin and moxifloxacin resistance in our geographical area.
methodsA prospective study from May 2019 to May 2023 was performed. MG-positive samples were collected. Real-time PCRs (AllplexTM MG-AziR Assay and AllplexTM MG-MoxiR Assay, Seegene) were performed in MG positive samples to detect mutations in 23S rRNA V domain and parC gene.
resultsA 37.1% of samples presented resistance determinants to azithromycin and the most common mutation detected was A2059G (57.9%). Resistance to moxifloxacin was studied in 72 azithromycin-resistant samples and 36.1% showed mutations, being G248T the most prevalent (73.1%).
conclusionsThe resistance to different lines of treat ment suggests the need for a targeted therapy and the performing of a test of cure afterwards.
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