Evidence map›Paper›PMID 38591247›Full record

ArticleThe Journal of infectious diseases2024

Pneumococci Isolated From Children in Community-Based Practice Differ From Isolates Identified by Population- and Laboratory-Based Invasive Disease Surveillance.

Ravinder Kaur, Ryan Gierke, Lesley McGee, Eduardo Gonzalez, Miwako Kobayashi, Michael Pichichero, Active Bacterial Core Surveillance (ABCs) Team

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The microbiological characteristics and diagnosis ofHuman vaccines & immunotherapeutics · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ravinder KaurCenter for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York.
Ryan GierkeDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Lesley McGeeDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Eduardo GonzalezCenter for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York.
Miwako KobayashiDivision of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Michael PichicheroCenter for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, New York.ORCID 0000-0002-8276-3938
Active Bacterial Core Surveillance (ABCs) Team

Funding

NTHi Immunity in Young ChildrenR01DC008671 · NIDCD · UNIVERSITY OF ROCHESTER · PI PICHICHERO, MICHAEL E · 2007 to 2016
$5.8M
CDC HHS 75D30119C06842, PI: M. P.NIDCD NIH HHS R01 DC008671US National Institute on Deafness and Communication Disorders R0108671
6 · The paper itself

Abstract

backgroundCharacterizing strains causing noninvasive and invasive pneumococcal disease (IPD) may inform the impact of new pneumococcal conjugate vaccines (PCVs).

methodsDuring 2011-2019, among children aged 6-36 months, pneumococcal serotype distribution and antibiotic nonsusceptibility of nasopharyngeal and middle ear fluid (MEF) isolates collected at onset of acute otitis media (AOM) in Rochester, New York, were compared with IPD isolates from the Active Bacterial Core surveillance (ABCs) system across 10 US sites.

resultsFrom Rochester, 400 (nasopharyngeal) and 156 (MEF) pneumococcal isolates were collected from 259 children. From ABCs, 907 sterile-site isolates were collected from 896 children. Non-PCV serotypes 35B and 21 were more frequent among the Rochester AOM cases, while serotypes 3, 19A, 22F, 33F, 10A, and 12F contained in PCVs were more frequent among ABCs IPD cases. The proportion of antibiotic-nonsusceptible pneumococcal isolates was generally more common among IPD cases. In 2015-2019, serotype 35B emerged as the most common serotype associated with multiclass antibiotic nonsusceptibility for both the Rochester AOM and ABCs IPD cases.

conclusionsPneumococcal isolates from children in Rochester with AOM differ in serotype distribution and antibiotic susceptibility compared to IPD cases identified through US surveillance. Non-PCV serotype 35B emerged as a common cause of AOM and IPD.

Indexed as

Otitis MediaPneumococcal InfectionsSerogroupStreptococcus pneumoniaeAnti-Bacterial AgentsChild, PreschoolFemaleHumansInfantMaleMicrobial Sensitivity TestsNasopharynxNew YorkPneumococcal VaccinesPopulation SurveillanceUnited StatesAnti-Bacterial AgentsPneumococcal VaccinesPCV13PCV15PCV20pneumococcal serotypesStreptococcus pneumoniae

Identifiers

PMID38591247
PMCPMC11565899

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.