Evidence map›Paper›PMID 38591148›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis.

Genta Kakiyama, Kei Minoiwa, Nanah Bai-Kamara, Taishi Hashiguchi, William M Pandak, Daniel Rodriguez-Agudo

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. StarD5 Plays a Critical Role in the Hepatocyte ER Stress Survival Response.International journal of molecular sciences · 2025
    Article
  4. Nonvesicular cholesterol transport in physiology.The Journal of clinical investigation · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Genta KakiyamaDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States.ORCID 0000-0002-0366-6903
Kei MinoiwaDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States.
Nanah Bai-KamaraResearch Services, Central Virginia Veterans Affairs Healthcare System, Richmond, Virginia, United States.
Taishi HashiguchiResearch and Development Bureau, SMC Laboratories, Inc., Tokyo, Japan.
William M PandakDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States.
Daniel Rodriguez-AgudoDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States.ORCID 0000-0002-5521-6314
Virginia Commonwealth University · USSMC Corporation (Japan) · JP

Funding

Role of Cholesterol in Non Alcoholic Fatty LiverI01BX000197 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI PANDAK, WILLIAM M · 2009 to 2021
–
An ER Stress Inducible START Domain Cholesterol Transport Protein, StarD5; and Unique Role in Fatty Liver DiseaseI01BX005895 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI WILLIAM M PANDAK · 2024 to 2026
–
BLRD VA I01 BX005895U.S. Department of Veterans Affairs (VA) I01 BX005895-01A2VCU | School of Medicine, Virginia Commonwealth University (VCU Med School) 411456VCU | School of Medicine, Virginia Commonwealth University (VCU Med School) 411864
6 · The paper itself

Abstract

Insufficient expression of steroidogenic acute regulatory-related lipid transfer protein 5 (StarD5) on liver cholesterol/lipid homeostasis is not clearly defined. The ablation of StarD5 was analyzed in mice on a normal or Western diet (WD) to determine its importance in hepatic lipid accumulation and fibrosis compared with wild-type (WT) mice. Rescue experiments in

Indexed as

Insulin ResistanceLiverLiver CirrhosisMice, KnockoutAdaptor Proteins, Vesicular TransportAnimalsCholesterolDiet, WesternDisease ProgressionFatty LiverHepatocytesHumansLipid MetabolismMaleMiceMice, Inbred C57BLAdaptor Proteins, Vesicular TransportCholesterolStard5 protein, mouseTriglyceridescholesterolfatty liverinsulin resistancetransportertriglycerides

Identifiers

PMID38591148
PMCPMC11376981
OpenAlexW4394594365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.