ReviewFrontiers in nutrition2024
Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders.
Review in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of aerobic exercise on body composition in children and adolescents with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials.BMC public health · 2025Pooled it
- Prenatal adipose tissue estimation using early second trimester anthropometry.European journal of clinical nutrition · 2026Article
- Adipose tissue depots and blood pressure regulation: mechanisms, biomarkers, and targets beyond obesity.American journal of hypertension · 2026Review
- Article
- Birth Weight, Adult Fat Distribution, and Type 2 Diabetes Mellitus Risk: Sex-Specific Study in a Large Prospective Cohort.Diabetes & metabolism journal · 2026Article
- Clinical and metabolic characteristics of acquired partial lipodystrophy: insights from a multicenter study.Journal of endocrinological investigation · 2026Article
- Body composition changes during cardiac rehabilitation and long-term cardiovascular outcomes in patients with coronary artery disease.American heart journal plus : cardiology research and practice · 2026Article
- Effects of an 8-Week Time-Restricted Eating and Walking Exercise on Regional Fat Distribution and Lean Mass in Women with Hidden Obesity: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of aging.GeroScience · 2026Review
- Article
- Dietary nutrient intake and nutritional status in women with infertility: a cross-sectional study.Scientific reports · 2026Article
- Exposome-wide patterns predict brain health in aging.Nature communications · 2026Article
- Associations between Body Composition Patterns, Brain Diseases and Injuries, and Risk of Epilepsy: A Prospective Cohort Study.Neuroepidemiology · 2026Article
- Comparison of body composition in female college students with different degrees of obesity.Scientific reports · 2026Article
- Nutrition Patterns, Metabolic and Psychological State Among High-Weight Young Adults: A Network Approach.Nutrients · 2026Article
- Adipose tissue distribution in metabolic disease: depot-specific biology, clinical assessment, and therapeutic remodeling.Frontiers in endocrinology · 2026Review
- Misclassification Bias in the Waist-To-Hip Ratio: Implications for Obesity-Related Risk of Incident Type 2 Diabetes.International journal of endocrinology · 2026Article
- Trunk-to-Appendicular Fat Ratio and Blood Pressure: Survey-Weighted Regression, Spline Modeling, and Exploratory Lipid Attenuation Analysis.International journal of hypertension · 2026Article
- Article
- Machine learning-based estimation of trunk fat percentage and its association with cardiometabolic risk leveraging two large national cohorts.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a major health problem that affects millions of individuals, and it is associated with metabolic diseases including insulin resistance (IR), type 2 diabetes (T2D), and cardiovascular diseases (CVDs). However, Body fat distribution (BFD) rather than crude obesity is now considered as a more accurate factor associated with these diseases. The factors affecting BFD vary, from genetic background, epigenetic factors, ethnicity, aging, hormonal changes, to lifestyle and medication consumptions. The main goal of controlling BFD comes from the fact that fat accumulation in different depots has a different effect on the overall health and metabolic health of individuals. It is well established that fat storage in the abdominal visceral depot is associated with metabolic disorder occurrence, while gluteal-femoral subcutaneous fat depot seems to be protective against these diseases. In this paper, we will summarize the factors affecting fat distribution. Then, we will present evidence connecting gluteal-femoral fat depot with protection against metabolic disorders including IR, T2D, and CVDs. Finally, we will list the suggested mechanisms that lead to this protective effect. The abstract is visualized in Graphical Abstract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.