Evidence map›Paper›PMID 38590789›Full record

ReviewFrontiers in psychiatry2024

Investigating the structural network underlying brain-immune interactions using combined histopathology and neuroimaging: a critical review for its relevance in acute and long COVID-19.

Zora Kikinis, Agustin Castañeyra-Perdomo, José Luis González-Mora, Richard Jarrett Rushmore, Poliana Hartung Toppa, Kayley Haggerty, George Papadimitriou, Yogesh Rathi, Marek Kubicki, Ron Kikinis and 5 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 4 countries.

Zora KikinisDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Agustin Castañeyra-PerdomoUniversidad de La Laguna, Área de Anatomía y Fisiología. Departamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, San Cristobal de la Laguna, Spain.
José Luis González-MoraUniversidad de La Laguna, Área de Anatomía y Fisiología. Departamento de Ciencias Médicas Básicas, Facultad de Ciencias de la Salud, San Cristobal de la Laguna, Spain.
Richard Jarrett RushmoreDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Poliana Hartung ToppaDepartments of Psychiatry and Neurology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Kayley HaggertyDepartments of Psychiatry and Neurology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
George PapadimitriouDepartments of Psychiatry and Neurology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Yogesh RathiDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Marek KubickiDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Ron KikinisDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Carina HellerDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Edward YeterianDepartments of Psychiatry and Neurology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Bianca BesteherDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Stefano PallantiDepartment of Psychiatry and Behavioural Science, Albert Einstein College of Medicine, Bronx, NY, United States.
Nikos MakrisDepartment of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Athinoula A. Martinos Center for Biomedical Imaging · USHarvard University · USJena University Hospital · DEMassachusetts General Hospital · USUniversidad de La Laguna · ESBrigham and Women's Hospital · USNeuroscience Institute · IT

Funding

Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1M
High Resolution, Comprehensive Atlases of the Human Brain MorphologyR01MH112748 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN, KUBICKI, MAREK · 2018 to 2022
$4.1M
Unraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography ValidationR01NS125307 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NIKOLAOS MAKRIS, RICHARD Jarrett RUSHMORE · 2022 to 2026
$3.4M
Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCDR01MH111917 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, MAKRIS, NIKOLAOS · 2017 to 2019
$2.1M
Mentoring and neuroimaging research on new targets for DBS in OCDK24MH116366 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MAKRIS, NIKOLAOS · 2018 to 2022
$817k
Modulating Inhibitory Control Networks In Gambling Disorder With Theta Burst StimulationR21DA042271 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI CAMPRODON, JOAN A, MAKRIS, NIKOLAOS · 2017 to 2018
$439k
NIA NIH HHS R01 AG042512NIDA NIH HHS R21 DA042271NIMH NIH HHS K24 MH116366NIMH NIH HHS R01 MH111917NIMH NIH HHS R01 MH112748NIMH NIH HHS R01 MH125860NINDS NIH HHS R01 NS125307
6 · The paper itself

Abstract

Current views on immunity support the idea that immunity extends beyond defense functions and is tightly intertwined with several other fields of biology such as virology, microbiology, physiology and ecology. It is also critical for our understanding of autoimmunity and cancer, two topics of great biological relevance and for critical public health considerations such as disease prevention and treatment. Central to this review, the immune system is known to interact intimately with the nervous system and has been recently hypothesized to be involved not only in autonomic and limbic bio-behaviors but also in cognitive function. Herein we review the structural architecture of the brain network involved in immune response. Furthermore, we elaborate upon the implications of inflammatory processes affecting brain-immune interactions as reported recently in pathological conditions due to SARS-Cov-2 virus infection, namely in acute and post-acute COVID-19. Moreover, we discuss how current neuroimaging techniques combined with

Indexed as

acute COVID-19brain-immune interactionshistopathologyinflammatory reflexneuroimagingneuroinflammationPASCpost-acute or long COVID-19

Identifiers

PMID38590789
PMCPMC11000670
OpenAlexW4393144320

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.