Evidence map›Paper›PMID 38590397›Full record

ArticleAmerican journal of cancer research2024

Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer.

Xi Wang, Min-Min Wu, Wei Zhang, Zhen-Qiong Liu, Meng-Qi Xu, Feng-Mei Zhang, Zhi-Qiang He, Dong-E Tang, Min Tang, Yong Dai

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xi WangClinical Medical Research Center, The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology Shenzhen 518055, Guangdong, China.
Min-Min WuHealth Science Center, South China Hospital, Shenzhen University Shenzhen 518020, Guangdong, China.
Wei ZhangClinical Medical Research Center, The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology Shenzhen 518055, Guangdong, China.
Zhen-Qiong LiuKey Laboratory of Diagnostic Medicine Designated by The Chinese Ministry of Education, Chongqing Medical University Chongqing 400016, China.
Meng-Qi XuKey Laboratory of Diagnostic Medicine Designated by The Chinese Ministry of Education, Chongqing Medical University Chongqing 400016, China.
Feng-Mei ZhangKey Laboratory of Diagnostic Medicine Designated by The Chinese Ministry of Education, Chongqing Medical University Chongqing 400016, China.
Zhi-Qiang HeKey Laboratory of Diagnostic Medicine Designated by The Chinese Ministry of Education, Chongqing Medical University Chongqing 400016, China.
Dong-E TangClinical Medical Research Center, The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology Shenzhen 518055, Guangdong, China.
Min TangKey Laboratory of Diagnostic Medicine Designated by The Chinese Ministry of Education, Chongqing Medical University Chongqing 400016, China.
Yong DaiClinical Medical Research Center, The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology Shenzhen 518055, Guangdong, China.
Southern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of vesicular genes in the development of colorectal cancer (CRC) is crucial. Analyzing alterations in these genes at multi-omics can aid in understanding the molecular pathways behind colorectal carcinogenesis and identifying potential treatment targets. However, studies on the overall alteration of vesicular genes in CRC are still lacking. In this study, we aimed to investigate the relationship between vesicle genetic alterations and CRC progression. To achieve this, we analyzed molecular alterations in CRC vesicle genes at eight levels, including mRNA, protein, and epigenetic levels. Additionally, we examined CRC overall survival-related genes that were obtained from a public database. Our analysis of chromatin structural variants, DNA methylation, chromatin accessibility, and proteins (including phosphorylation, ubiquitination, and malonylation), along with RNA-seq data from the TCGA database, revealed multiple levels of alterations in CRC vesicle genes in the collected tissue samples. We progressively examined the alterations of vesicle genes in mRNA and protein levels in CRC and discovered the hub genes. Further investigation identified the probable essential transcription factors. This study contributes to a thorough knowledge of the connection between vesicle gene alterations at multiple levels and the development of CRC and offers a theoretical framework for the identification of novel treatment targets.

Indexed as

Human colorectal cancermechanisms of diseasemulti-omics analysistherapeutic targetsvesicle genes

Identifiers

PMID38590397
PMCPMC10998746
OpenAlexW4393985263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.