Evidence map›Paper›PMID 38590295›Full record

ReviewCell transplantation

Cell Transplantation for Repair of the Spinal Cord and Prospects for Generating Region-Specific Exogenic Neuronal Cells.

Alex Roman, Anne Huntemer-Silveira, Madison A Waldron, Zainab Khalid, Jeffrey Blake, Ann M Parr, Walter C Low

Open access · goldAbstract readReview
In one paragraph

Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Wrap it up: myelination of transplanted neurons for repair.Frontiers in cellular neuroscience · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alex RomanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-1500-9764
Anne Huntemer-SilveiraDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Madison A WaldronDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Zainab KhalidDepartment of Neurosurgery, Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA.
Jeffrey BlakeDepartment of Neurosurgery, Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA.
Ann M ParrGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Walter C LowGraduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8593-0175
University of Minnesota · US

Funding

Generating Exogenic Organs for Transplantation without the Use of ImmunosuppressionR01AI173804 · NIAID · UNIVERSITY OF MINNESOTA · PI WALTER C LOW, CLIFFORD John STEER · 2022 to 2026
$3.7M
Predoctoral Training of NeuroscientistsT32NS105604 · NINDS · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2018 to 2026
$3.5M
3D Bioprinted Spinal Cord Organoids as a Relay System for Spinal Cord InjuryR01NS119297 · NINDS · UNIVERSITY OF MINNESOTA · PI PARR, ANN M · 2021 to 2025
$2.4M
NIAID NIH HHS R01 AI173804NINDS NIH HHS R01 NS119297NINDS NIH HHS T32 NS105604
6 · The paper itself

Abstract

Spinal cord injury (SCI) is associated with currently irreversible consequences in several functional components of the central nervous system. Despite the severity of injury, there remains no approved treatment to restore function. However, with a growing number of preclinical studies and clinical trials, cell transplantation has gained significant potential as a treatment for SCI. Researchers have identified several cell types as potential candidates for transplantation. To optimize successful functional outcomes after transplantation, one key factor concerns generating neuronal cells with regional and subtype specificity, thus calling on the developmental transcriptome patterning of spinal cord cells. A potential source of spinal cord cells for transplantation is the generation of exogenic neuronal progenitor cells via the emerging technologies of gene editing and blastocyst complementation. This review highlights the use of cell transplantation to treat SCI in the context of relevant developmental gene expression patterns useful for producing regionally specific exogenic spinal cells via

Indexed as

Spinal Cord InjuriesStem Cell TransplantationHumansNeuronsSpinal Cordblastocyst complementationcell transplantationneural progenitor cellsregenerative medicinespinal cord injury

Identifiers

PMID38590295
PMCPMC11005494
OpenAlexW4394612219

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.