ArticleEndocrinology, diabetes & metabolism2024
Association of Three Novel Inflammatory Markers: Lymphocyte to HDL-C Ratio, High-Sensitivity C-Reactive Protein to HDL-C Ratio and High-Sensitivity C-Reactive Protein to Lymphocyte Ratio With Metabolic Syndrome.
Article in Endocrinology, diabetes & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- High-density lipoprotein-related inflammatory markers and their association with all-cause and cardiovascular mortality in an ageing population: findings from a prospective cohort study based on NHANES data.Journal of global health · 2026Article
- Association of novel inflammation markers derived from high-sensitivity C-reactive protein with anemia: a cross-sectional study based on NHANES 2015-2018.Thrombosis journal · 2026Article
- Association between lymphocyte to high-density lipoprotein ratio and total bone mineral density in 8-19-year-old children and adolescents: a cross-sectional study.European journal of medical research · 2026Article
- Lymphocyte-to-high-density lipoprotein ratio is negatively associated with diabetic macular edema in type 2 diabetic patients.Frontiers in endocrinology · 2026Article
- HDL-Adjusted Inflammatory Ratios and Sequential Graft Configuration are Associated with Mid-Term Saphenous Vein Graft Occlusion in a Post-CABG Angiography Cohort.Journal of inflammation research · 2026Article
- HDL-related lipid ratios reflecting metabolic inflammation are associated with endometriosis status and ASRM stage.Frontiers in physiology · 2026Article
- U-shaped association between lymphocyte-to-high-density lipoprotein ratio and all-cause mortality in patients with chronic obstructive pulmonary disease: insights from a population-based cohort study.Journal of thoracic disease · 2025Article
- A machine learning-based framework for predicting metabolic syndrome using serum liver function tests and high-sensitivity C-reactive protein.Scientific reports · 2025Article
- Introducing Two Novel Indices for Evaluating Coronary Artery Stenosis: Athero-Inflammatory Index and Athero-Inflammatory Glucose Index.Journal of clinical laboratory analysis · 2025Article
- Relationship between novel inflammatory markers derived from high-sensitivity C-reactive protein and heart failure: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Sex differences in associations of metabolic inflammation and insulin resistance with incident type 2 diabetes mellitus: a retrospective cohort of adults with annual health examinations.Lipids in health and disease · 2025Article
- Association between lymphocyte to high-density lipoprotein cholesterol ratio and insulin resistance and metabolic syndrome in US adults: results from NHANES 2007-2018.Lipids in health and disease · 2025Article
- Early-pregnancy HDL-related inflammatory indices and risk of preeclampsia: A retrospective cohort study.PloS one · 2025Article
- Threshold Effect of the Lymphocyte to HDL-C Ratio on the Risk of Stroke-Associated Pneumonia After Acute Ischemic Stroke: A Retrospective Cohort Study.Journal of inflammation research · 2025Article
- Platelet to high density lipoprotein cholesterol ratio is associated with diabetes and prediabetes in NHANES 2005 to 2018.Scientific reports · 2024Article
- Association between monocyte-to-high-density lipoprotein cholesterol ratio and stroke: a propensity score matched cross-sectional study.Frontiers in neurologyArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to compare the association of three novel inflammatory indicators with metabolic syndrome (MetS) among Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort participants.
methodsAccording to the International Diabetes Federation (IDF) criteria, the cohort participants were divided into the MetS(+) and MetS(-) groups. The lymphocyte to high-density lipoprotein cholesterol (HDL-C) ratio (LHR), high-sensitivity C-reactive protein (hs-CRP) to HDL-C ratio (HCHR) and hs-CRP to lymphocyte ratio (HCLR) were calculated and were compared between the groups. Binary logistic regression (LR) analysis was performed to find the association of the indices with the presence of MetS among men and women. Receiver-operating characteristic (ROC) curve analysis was used to establish cut-off values in predicting MetS for men and women. p-Values <0.05 were considered as statistically significant.
resultsAmong a total of 8890 participants (5500 MetS(-) and 3390 MetS(+)), LHR, HCHR and HCLR were significantly higher in the MetS(+) group than in MetS(-) group (p < 0.001). In LR analysis, after adjusting for multiple cofounders, LHR remained an independent factor for the presence of MetS among men (OR: 1.254; 95% CI: 1.202-1.308; p < 0.001) and women (OR: 1.393; 95% CI: 1.340-1.448; p < 0.001). HCHR also remained an independent factor for the presence of MetS only in women (OR: 1.058; 95% CI: 1.043-1.073; p < 0.001). ROC curve analysis showed that LHR had the higher AUC for predicting MetS in both men (AUC: 0.627; 95% CI: 0.611-0.643; p < 0.001) and women (AUC: 0.683; 95% CI: 0.670, 0.696; p < 0.001).
conclusionThis suggests that among both genders, the LHR as an inexpensive and easy-to-access marker has a better diagnostic performance and could be a promising alternative to the traditional expensive inflammatory markers such as hs-CRP for the evaluation of inflammation in patients with MetS.
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