ArticleAnnals of clinical and translational neurology2024
Multifeature quantitative motor assessment of upper limb ataxia including drawing and reaching.
Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Three-dimensional Motion Capture Discriminates Extremely Mild Cerebellar Ataxia from Parkinsonism in the Upper Limbs.Cerebellum (London, England) · 2026Article
- In vivo mapping of striatal neurodegeneration in Huntington's disease with Soma and Neurite Density Imaging.eLife · 2026Article
- Digital Motor Outcomes Capture Upper Limb and Mild Stage Impairment in Hereditary Spastic Paraplegia.Neurology and therapy · 2026Article
- Machine Learning Aided Kinematic Profiling of Reaching Movements Separates Spinocerebellar Ataxia type 12 and Essential Tremor.Cerebellum (London, England) · 2026Article
- MT-ATP6 9035T>C Variant Causes Ataxia With Azoospermia and Apparent Anticipation in a Four-generation Kindred.Cerebellum (London, England) · 2026Observational
- Quantitative Assessment of Upper Limb Ataxia Using a Virtual Reality-Based Evaluation System.Annals of clinical and translational neurology · 2026Article
- Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases.CPT: pharmacometrics & systems pharmacology · 2025Observational
- Digital Outcomes of Upper Limb Ataxia Capture Meaningful Longitudinal Change and Treatment Response.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Clinical Applications and Measurement Properties of the Digitized Archimedes Spiral Drawing Test: A Scoping Review.Movement disorders clinical practice · 2025Article
- Comparing randomized trial designs to estimate treatment effect in rare diseases with longitudinal models: a simulation study showcased by Autosomal Recessive Cerebellar Ataxias using the SARA score.BMC medical research methodology · 2025Article
- Biomarkers in Spinocerebellar Ataxias.Cerebellum (London, England) · 2025Review
- Smartphone Application for Spastic Ataxias Cross-Sectional Validation of a Newly Developed Smartphone App for Remote Monitoring in Spastic Ataxias.Cerebellum (London, England) · 2025Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
objectiveVoluntary upper limb movements are an ecologically important yet insufficiently explored digital-motor outcome domain for trials in degenerative ataxia. We extended and validated the trial-ready quantitative motor assessment battery "Q-Motor" for upper limb movements with clinician-reported, patient-focused, and performance outcomes of ataxia.
methodsExploratory single-center cross-sectional assessment in 94 subjects (46 cross-genotype ataxia patients; 48 matched controls), comprising five tasks measured by force transducer and/or position field: Finger Tapping, diadochokinesia, grip-lift, and-as novel implementations-Spiral Drawing, and Target Reaching. Digital-motor measures were selected if they discriminated from controls (AUC >0.7) and correlated-with at least one strong correlation (rho ≥0.6)-to the Scale for the Assessment and Rating of Ataxia (SARA), activities of daily living (FARS-ADL), and the Nine-Hole Peg Test (9HPT).
resultsSix movement features with 69 measures met selection criteria, including speed and variability in all tasks, stability in grip-lift, and efficiency in Target Reaching. The novel drawing/reaching tasks best captured impairment in dexterity (|rho
interpretationQ-Motor assessment captures multiple features of impaired upper limb movements in degenerative ataxia. Validation with key clinical outcome domains provides the basis for evaluation in longitudinal studies and clinical trial settings.
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