Evidence map›Paper›PMID 38589896›Full record

ArticleVirology journal2024

Development of monoclonal antibodies against oropouche virus and its applicability to immunohistochemical diagnosis.

Ana Paula Andreolla, Alessandra Abel Borges, Seigo Nagashima, Caroline Busatta Vaz de Paula, Lucia de Noronha, Nilson I T Zanchin, Juliano Bordignon, Claudia Nunes Duarte Dos Santos

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. A bibliometric analysis of Oropouche virus.Frontiers in microbiology · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ana Paula AndreollaLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz PR, Cidade Industrial de Curitiba, Rua Prof. Algacyr Munhoz Mader 3775, Curitiba, Paraná, Brazil.
Alessandra Abel BorgesLaboratório de Pesquisas em Virologia e Imunologia, Instituto de Ciências Biológicas e da Saúde (ICBS), Universidade Federal de Alagoas (UFAL), Av. Lourival Melo Mota, s/n, Tabuleiro do Martins, Maceió, Alagoas, Brazil.
Seigo NagashimaLaboratório de Patologia Experimental, Pontifica Universidade Católica do Paraná (PUC/PR), Rua Imaculada Conceição, 1155, Prado Velho, Curitiba, Paraná, Brazil.
Caroline Busatta Vaz de PaulaLaboratório de Patologia Experimental, Pontifica Universidade Católica do Paraná (PUC/PR), Rua Imaculada Conceição, 1155, Prado Velho, Curitiba, Paraná, Brazil.
Lucia de NoronhaLaboratório de Patologia Experimental, Pontifica Universidade Católica do Paraná (PUC/PR), Rua Imaculada Conceição, 1155, Prado Velho, Curitiba, Paraná, Brazil.
Nilson I T ZanchinLaboratório de Biologia Estrutural e Engenharia de Proteínas, Instituto Carlos Chagas, ICC/Fiocruz PR, Cidade Industrial de Curitiba, Rua Prof. Algacyr Munhoz Mader 3775, Curitiba, Paraná, Brazil.
Juliano BordignonLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz PR, Cidade Industrial de Curitiba, Rua Prof. Algacyr Munhoz Mader 3775, Curitiba, Paraná, Brazil. juliano.bordignon@fiocruz.br.
Claudia Nunes Duarte Dos SantosLaboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz PR, Cidade Industrial de Curitiba, Rua Prof. Algacyr Munhoz Mader 3775, Curitiba, Paraná, Brazil. claudia.dossantos@fiocruz.br.
Fundação Carlos Chagas · BRPontifícia Universidade Católica do Paraná · BRUniversidade Federal de Alagoas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orthobunyavirus oropouche ense virus (OROV), the causative agent of Oropouche fever, is widely dispersed in Brazil and South America, causing sporadic outbreaks. Due to the similarity of initial clinical symptoms caused by OROV with other arboviruses found in overlapping geographical areas, differential diagnosis is challenging. As for most neglected tropical diseases, there is a shortage of reagents for diagnosing and studying OROV pathogenesis. We therefore developed and characterized mouse monoclonal antibodies and, one of them recognizes the OROV nucleocapsid in indirect immunofluorescent (IFA) and immunohistochemistry (IHC) assays. Considering that it is the first monoclonal antibody produced for detecting OROV infections, we believe that it will be useful not only for diagnostic purposes but also for performing serological surveys and epidemiological surveillance on the dispersion and prevalence of OROV in Brazil and South America.

Indexed as

Bunyaviridae InfectionsOrthobunyavirusAnimalsAntibodies, MonoclonalBrazilMiceAntibodies, MonoclonalImmune-histochemistry diagnosisIndirect immunofluorescent assayMonoclonal antibodyNeglected virusOropouche virus

Identifiers

PMID38589896
PMCPMC11000289
OpenAlexW4394578155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.