Evidence map›Paper›PMID 38589875›Full record

Trial reportJournal of neuroengineering and rehabilitation2024

Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial.

Chi-Shou Chang, Chia-Ling Chen, Rou-Shayn Chen, Hsieh-Ching Chen, Chung-Yao Chen, Chia-Ying Chung, Katie Pei-Hsuan Wu, Ching-Yi Wu, Keh-Chung Lin

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04265365 (Efficacy of Integrated Therapy of Repetitive Transcranial Magnetic Stimulation and Repetitive Peripheral Magnetic Stimulation on Upper Limb Function in Patients With Stroke), which is not on this map. Cited by 18 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 8 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04265365 naunknown statusnot on this map

Efficacy of Integrated Therapy of Repetitive Transcranial Magnetic Stimulation and Repetitive Peripheral Magnetic Stimulation on Upper Limb Function in Patients With Stroke

TypeinterventionalSponsorChang Gung Memorial HospitalRan2019 to 2023Enrolled90ConditionsStrokeArmsrTMS+rPMS_iTBS_R, rTMS+rPMS_cTBS_R, rTMS +sham-rPMS, rTMS+rPMS_iTBS_M/U, rTMS+rPMS_cTBS_M/U
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 8 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Effectiveness of intermittent theta burst stimulation (iTBS) on Post-Stroke motor dysfunction: A Meta-Analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Chi-Shou ChangDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Chia-Ling ChenDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan. clingchen@gmail.com.
Rou-Shayn ChenDepartment of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Hsieh-Ching ChenDepartment of Industrial Engineering and Management, National Taipei University of Technology, Taipei, Taiwan.
Chung-Yao ChenDepartment of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Chia-Ying ChungDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan.
Katie Pei-Hsuan WuDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan.
Ching-Yi WuDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan.
Keh-Chung LinSchool of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chang Gung University · TWChang Gung Memorial Hospital · TWMemorial Hospital of South Bend · USNational Central University · TWNational Taipei University of Technology · TWNational Taiwan University Hospital · TWXiamen Chang Gung Hospital · CN

Funding

Chang Gung Medical Foundation, Taiwan CMRPG3L0111-2National Science and Technology Council NSTC 108-2314-B-182-043
6 · The paper itself

Abstract

backgroundNon-invasive techniques such as central intermittent theta burst stimulation (iTBS) and repetitive peripheral magnetic stimulation (rPMS) have shown promise in improving motor function for patients with stroke. However, the combined efficacy of rPMS and central iTBS has not been extensively studied. This randomized controlled trial aimed to investigate the synergistic effects of rPMS and central iTBS in patients with stroke.

methodIn this study, 28 stroke patients were randomly allocated to receive either 1200 pulses of real or sham rPMS on the radial nerve of the affected limb, followed by 1200 pulses of central iTBS on the ipsilesional hemisphere. The patients received the intervention for 10 sessions over two weeks. The primary outcome measures were the Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and the Action Research Arm Test (ARAT). Secondary outcomes for activities and participation included the Functional Independence Measure-Selfcare (FIM-Selfcare) and the Stroke Impact Scale (SIS). The outcome measures were assessed before and after the intervention.

resultsBoth groups showed significant improvement in FMA-UE and FIM-Selfcare after the intervention (p < 0.05). Only the rPMS + iTBS group had significant improvement in ARAT-Grasp and SIS-Strength and activity of daily living (p < 0.05). However, the change scores in all outcome measures did not differ between two groups.

conclusionsOverall, the study's findings suggest that rPMS may have a synergistic effect on central iTBS to improve grasp function and participation. In conclusion, these findings highlight the potential of rPMS as an adjuvant therapy for central iTBS in stroke rehabilitation. Further large-scale studies are needed to fully explore the synergistic effects of rPMS on central iTBS.

trial registrationThis trial was registered under ClinicalTrials.gov ID No.NCT04265365, retrospectively registered, on February 11, 2020.

Indexed as

StrokeStroke RehabilitationDouble-Blind MethodHumansMagnetic PhenomenaTranscranial Magnetic StimulationTreatment OutcomeUpper ExtremityMotor functionParticipationPeripheral magnetic stimulationRehabilitationStrokeTheta burst stimulationUpper limb

Identifiers

PMID38589875
PMCPMC11000298
OpenAlexW4394577277

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.