ReviewBMC medical research methodology2024
Methods of determining optimal cut-point of diagnostic biomarkers with application of clinical data in ROC analysis: an update review.
Review in BMC medical research methodology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 2 of them syntheses that pooled it.
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Who cites it
125 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Host Plasma Protein Biomarkers for Tuberculosis Disease Screening in Febrile Adults in Tanzania.The Journal of infectious diseases · 2026Article
- Prospective development and validation of an objective classification for difficult facemask ventilation: the MASCAN score.Anaesthesia · 2026Article
- Diagnostic Efficacy of Clinico-Pathological Parameters in Predicting Nodal Positivity in Oral Cavity Squamous Cell Carcinoma: A Multivariate Risk Assessment.Medicina (Kaunas, Lithuania) · 2026Article
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- Toxicity-Tailored Thresholds of Delayed Methotrexate Elimination in Non-Hodgkin Lymphoma: A Population-Based Approach to Therapy Optimization.European journal of drug metabolism and pharmacokinetics · 2026Article
- Development of a prognostic prediction model for tumor recurrence or progression in gastrointestinal stromal tumors: integrating inflammatory blood indices with 5 mm2 versus 50 high-power field mitotic counts.Journal of pathology and translational medicine · 2026Article
- Sentinel serosurvey for Mpox virus infection among key populations in India: Evidence of sporadic past exposure beyond travel-related cases.The Indian journal of medical research · 2026Article
- An RNase domain-dependent microRNA detection with DNA-spiked nanocage for accurate cancer diagnosis.Nature communications · 2026Article
- Predicting Wound Complications Following Total Knee Arthroplasty: Preoperative Inflammatory Indices and a Novel Risk Scale (TKA-PII).Diagnostics (Basel, Switzerland) · 2026Article
- Study on the construction and verification of intraoperative pressure injury risk prediction model for children undergoing cardiac surgery.BMC pediatrics · 2026Article
- A two-stage hierarchical support vector machine framework detects roasted coffee adulterants through principal component analysis of hyperspectral imaging data.Scientific reports · 2026Article
- Tumor location and morphological MRI features in relation to combined 1p/22q deletion in meningioma.Discover oncology · 2026Article
- Investigation of Minimal Clinically Important Difference of the Extended Barthel Index in Inpatients With Acute to Subacute Stroke in China.Hong Kong journal of occupational therapy : HKJOT · 2026Article
- Extension of overlap measures for Multi-Class Biomarker Evaluation in Alzheimer's Disease.Scientific reports · 2026Article
65 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
introductionAn important application of ROC analysis is the determination of the optimal cut-point for biomarkers in diagnostic studies. This comprehensive review provides a framework of cut-point election for biomarkers in diagnostic medicine.
methodsSeveral methods were proposed for the selection of optional cut-points. The validity and precision of the proposed methods were discussed and the clinical application of the methods was illustrated with a practical example of clinical diagnostic data of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and malondialdehyde (MDA) for prediction of inflammatory bowel disease (IBD) patients using the NCSS software.
resultsOur results in the clinical data suggested that for CRP and MDA, the calculated cut-points of the Youden index, Euclidean index, Product and Union index methods were consistent in predicting IBD patients, while for ESR, only the Euclidean and Product methods yielded similar estimates. However, the diagnostic odds ratio (DOR) method provided more extreme values for the optimal cut-point for all biomarkers analyzed.
conclusionOverall, the four methods including the Youden index, Euclidean index, Product, and IU can produce quite similar optimal cut-points for binormal pairs with the same variance. The cut-point determined with the Youden index may not agree with the other three methods in the case of skewed distributions while DOR does not produce valid informative cut-points. Therefore, more extensive Monte Carlo simulation studies are needed to investigate the conditions of test result distributions that may lead to inconsistent findings in clinical diagnostics.
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