Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology.

Marina Minto Cararo-Lopes, Ratchell Sadovnik, Allen Fu, Shradha Suresh, Srinivasa Gandu, Bonnie L Firestein

Abstract read

In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Gene deletion of Klotho in the dentate gyrus does not affect the number of adult-born granule cells.Scientific reports · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marina Minto Cararo-LopesDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-6219-4726

Ratchell SadovnikDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0002-5817-0892

Allen FuDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-9046-6581

Shradha SureshDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-8379-8668

Srinivasa GanduDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.ORCID http://orcid.org/0000-0001-8288-1523

Bonnie L FiresteinDepartment of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. firestein@biology.rutgers.edu.ORCID http://orcid.org/0000-0002-1679-3565

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.175866/2018-01New Jersey Commission on Brain Injury Research CBIR20FEL009New Jersey Commission on Brain Injury Research CBIR20IRG003New Jersey Commission on Brain Injury Research CBIR22PIL020Rutgers, The State University of New Jersey Aresty Research Center

6 · The paper itself

Abstract

α-Klotho (α-Kl) is a modulator of aging, neuroprotection, and cognition. Transcription of the Klotho gene produces two splice variants-a membrane protein (mKl), which can be cleaved and released into the extracellular milieu, and a truncated secreted form (sKl). Despite mounting evidence supporting a role for α-Kl in brain function, the specific roles of α-Kl isoforms in neuronal development remain elusive. Here, we examined α-Kl protein levels in rat brain and observed region-specific expression in the adult that differs between isoforms. In the developing hippocampus, levels of isoforms decrease after the third postnatal week, marking the end of the critical period for development. We overexpressed α-Kl isoforms in primary cultures of rat cortical neurons and evaluated effects on brain-derived neurotrophic factor (BDNF) signaling. Overexpression of either isoform attenuated BDNF-mediated signaling and reduced intracellular Ca

Indexed as

Brain-Derived Neurotrophic FactorDendritesHippocampusKlotho ProteinsProtein IsoformsAnimalsCells, CulturedCell ShapeGlucuronidaseMaleNeuronsRatsRats, Sprague-DawleySignal TransductionBrain-Derived Neurotrophic FactorGlucuronidaseKlotho Protein, ratKlotho ProteinsProtein IsoformsBDNFCalciumDendrite branchingNeuronal developmentTrkB signalingα-Klotho

Identifiers

PMID38589756

DOI10.1038/nn.4348

PMCPMC11496329

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.