Evidence map›Paper›PMID 38589544›Full record

ArticleScientific reports2024

Evaluation of specific RBE in different cells of hippocampus under high-dose proton irradiation in rats.

Shengying Zhou, Xingchen Ding, Yiyuan Zhang, Yuanyuan Liu, Xiaowen Wang, Yujiao Guo, Jianguang Zhang, Xiao Liu, Guanzhong Gong, Ya Su and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. N-acetyl cysteine through modulation of HDACIBRO neuroscience reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Shengying Zhou *School of Clinical Medicine, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Xingchen Ding *Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, NO.440 Ji Yan Road, Jinan, 250117, Shandong, China.
Yiyuan Zhang *Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, NO.440 Ji Yan Road, Jinan, 250117, Shandong, China.
Yuanyuan LiuDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
Xiaowen WangDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, NO.440 Ji Yan Road, Jinan, 250117, Shandong, China.
Yujiao GuoAffiliated Hospital of Jining Medical College, Jining, 272067, Shandong, China.
Jianguang ZhangZibo Wanjie Cancer Hospital, Zibo, 255202, Shandong, China.
Xiao Liu960 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Jinan, 250031, Shandong, China.
Guanzhong GongDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, NO.440 Ji Yan Road, Jinan, 250117, Shandong, China.
Ya SuDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, NO.440 Ji Yan Road, Jinan, 250117, Shandong, China.
Lizhen WangDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, NO.440 Ji Yan Road, Jinan, 250117, Shandong, China.
Miaoqing ZhaoDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. zhaomqsd@163.com.
Man HuDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, NO.440 Ji Yan Road, Jinan, 250117, Shandong, China. human5770@163.com.
Shandong First Medical University · CNShandong Tumor Hospital · CNAffiliated Hospital of Jining Medical University · CNCentral Hospital of Zibo · CNPeople's Liberation Army 401 Hospital · CN

Funding

National Natural Science Foundation of China 82202958National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 82272751Natural Science Foundation of Shandong Province ZR2021LSW002Science Technology Program of Jinan 202225013Science Technology Program of Jinan 202225019Shandong provincial colleges and universities youth innovation technology support program 2023KJL004
6 · The paper itself

Abstract

The study aimed to determine the specific relative biological effectiveness (RBE) of various cells in the hippocampus following proton irradiation. Sixty Sprague-Dawley rats were randomly allocated to 5 groups receiving 20 or 30 Gy of proton or photon irradiation. Pathomorphological neuronal damage in the hippocampus was assessed using Hematoxylin-eosin (HE) staining. The expression level of NeuN, Nestin, Caspase-3, Olig2, CD68 and CD45 were determined by immunohistochemistry (IHC). The RBE range established by comparing the effects of proton and photon irradiation at equivalent biological outcomes. Proton

Indexed as

ProtonsProton TherapyAnimalsHippocampusNestinRatsRats, Sprague-DawleyRelative Biological EffectivenessNestinProtonsHippocampusNeuronal damageProton beam therapyRadiation-induced brain injuryRelative biological effectiveness

Identifiers

PMID38589544
PMCPMC11001863
OpenAlexW4394569952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.