Evidence map›Paper›PMID 38589377›Full record

ArticleScientific reports2024

Evaluation of sensitivity and specificity of Kato-Katz and circulating cathodic antigen in terms of Schistosoma japonicum using latent class analysis.

Mugyeom Moon, Hannah W Wu, Mario Jiz, Stephanie Maldonado, Jonathan D Kurtis, Jennifer F Friedman, Blanca Jarilla, Sangshin Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mugyeom MoonFood and Agriculture Organization of the United Nations, Regional Office for Asia and Pacific, Bangkok, Thailand.
Hannah W WuThe Warren Alpert Medical School of Brown University, Providence, RI, USA.
Mario JizDepartment of Health, Research Institute for Tropical Medicine, Manila, Philippines.
Stephanie MaldonadoThe Warren Alpert Medical School of Brown University, Providence, RI, USA.
Jonathan D KurtisThe Warren Alpert Medical School of Brown University, Providence, RI, USA.
Jennifer F FriedmanThe Warren Alpert Medical School of Brown University, Providence, RI, USA.
Blanca JarillaDepartment of Health, Research Institute for Tropical Medicine, Manila, Philippines.
Sangshin ParkThe Warren Alpert Medical School of Brown University, Providence, RI, USA. dvm.spark@gmail.com.

Funding

Optimizing interventions to mitigate schistosomiasis-related morbidity among pregnant women and childrenK24AI112964 · NIAID · RHODE ISLAND HOSPITAL · PI FRIEDMAN, JENNIFER F · 2015 to 2024
$1.7M
Schistosome VaccinesR01AI101274 · NIAID · RHODE ISLAND HOSPITAL · PI KURTIS, JONATHAN D. · 2013 to 2016
$1.6M
NIAID NIH HHS K24 AI112964NIAID NIH HHS R01 AI101274NIH HHS K24 AI112964-06NIH HHS R01 AI101274
6 · The paper itself

Abstract

Schistosoma japonicum is endemic in the Philippines. The Kato-Katz (KK) method was used to diagnose S. japonicum. This is impractical, particularly when the sample size is limited. Knowledge on point-of-care circulating cathodic antigen (CCA) test performance for S. japonicum is limited. Determining the sensitivity and specificity of new diagnostics is difficult when the gold standard test is less effective or absent. Latent class analysis (LCA) can address some limitations. A total of 484 children and 572 adults from the Philippines were screened for S. japonicum. We performed Bayesian LCA to estimate the infection prevalence, sensitivity and specificity of each test by stratifying them into two age groups. Observed prevalence assessed by KK was 50.2% and 31.8%, and by CCA was 89.9% and 66.8%, respectively. Using Bayesian LCA, among children, the sensitivity and specificity of CCA were 94.8% (88.7-99.4) and 21.5% (10.5-36.1) while those of KK were 66.0% (54.2-83.3) and 78.1% (61.1-91.3). Among adults, the sensitivity and specificity of CCA were 86.4% (76.6-96.9) and 62.8% (49.1-81.1) while those of KK were 43.6% (35.1-53.9) and 85.5% (75.8-94.6). Overall, CCA was more sensitive than KK, regardless of the age group at diagnosis, as KK was more specific. KK and CCA have different diagnostic performance, which should inform their use in the planning and implementation of S. japonicum control programs.

Indexed as

Schistosoma japonicumSchistosomiasis mansoniAdultAnimalsAntigens, HelminthBayes TheoremChildFecesHumansLatent Class AnalysisPoint-of-Care SystemsPrevalenceSchistosoma mansoniSensitivity and SpecificityAntigens, Helminth

Identifiers

PMID38589377
PMCPMC11001968

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