Evidence map›Paper›PMID 38589375›Full record

ArticleNature communications2024

Metabolic plasticity, essentiality and therapeutic potential of ribose-5-phosphate synthesis in Toxoplasma gondii.

Xuefang Guo, Nuo Ji, Qinghong Guo, Mengting Wang, Huiyu Du, Jiajia Pan, Lihua Xiao, Nishith Gupta, Yaoyu Feng, Ningbo Xia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. TreC: A Critical Mediator of lysoPC-Induced Hypervirulence inTransboundary and emerging diseases · 2026
    Article
  4. Uridine as a hub in cancer metabolism and RNA biology.Experimental & molecular medicine · 2025
    Review
  5. Low temperature increases adenovirus replication via intracellular alkalization.Frontiers in cellular and infection microbiology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Xuefang Guo *State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
Nuo Ji *State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
Qinghong GuoState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
Mengting WangState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
Huiyu DuState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
Jiajia PanState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.
Lihua XiaoState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China.ORCID http://orcid.org/0000-0001-8532-2727
Nishith GuptaIntracellular Parasite Education and Research Labs (iPEARL), Department of Biological Sciences, Birla Institute of Technology and Science, Pilani (BITS-P), Hyderabad, India. Gupta.Nishith@hyderabad.bits-pilani.ac.in.ORCID http://orcid.org/0000-0003-1452-5126
Yaoyu FengState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China. yyfeng@scau.edu.cn.
Ningbo XiaState Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, China. ningboxia@scau.edu.cn.ORCID http://orcid.org/0000-0002-6090-7400
South China Agricultural University · CNHumboldt-Universität zu Berlin · DE

Funding

DBT-Wellcome Trust India Alliance IA/S/19/1/504263Wellcome Trust
6 · The paper itself

Abstract

Ribose-5-phosphate (R5P) is a precursor for nucleic acid biogenesis; however, the importance and homeostasis of R5P in the intracellular parasite Toxoplasma gondii remain enigmatic. Here, we show that the cytoplasmic sedoheptulose-1,7-bisphosphatase (SBPase) is dispensable. Still, its co-deletion with transaldolase (TAL) impairs the double mutant's growth and increases

Indexed as

ToxoplasmaDiphosphatesGlycolysisPentose Phosphate PathwayRibosemonophosphatesDiphosphatesribose-5-phosphateRibosemonophosphates

Identifiers

PMID38589375
PMCPMC11001932
OpenAlexW4394573348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.