Evidence map›Paper›PMID 38588958›Full record

ReviewAdvanced drug delivery reviews2024

Delivery technologies for therapeutic targeting of fibronectin in autoimmunity and fibrosis applications.

Jacob D Bonadio, Ghazal Bashiri, Patrick Halligan, Michael Kegel, Fatima Ahmed, Karin Wang

Open access · greenAbstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jacob D BonadioDepartment of Bioengineering, Temple University, Philadelphia, PA, United States.
Ghazal BashiriDepartment of Bioengineering, Temple University, Philadelphia, PA, United States.
Patrick HalliganDepartment of Bioengineering, Temple University, Philadelphia, PA, United States.
Michael KegelDepartment of Bioengineering, Temple University, Philadelphia, PA, United States.
Fatima AhmedDepartment of Bioengineering, Temple University, Philadelphia, PA, United States.
Karin WangDepartment of Bioengineering, Temple University, Philadelphia, PA, United States. Electronic address: karin.wang@temple.edu.
Temple University · US

Funding

MARC at Temple UniversityT34GM136494 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI MA, GRACE X., MATSIKA, SPIRIDOULA · 2020 to 2024
$2.1M
NIGMS NIH HHS T34 GM136494
6 · The paper itself

Abstract

Fibronectin (FN) is a critical component of the extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with other ECM proteins, growth factors, cells, and associated signaling pathways, thus influencing the progress of diseases such as fibrosis and autoimmune disorders. Therefore, developing therapeutics that directly target FN or its interaction with cells and other ECM components can be an intriguing approach to address autoimmune and fibrosis pathogenesis.

Indexed as

FibronectinsFibrosisAnimalsAutoimmune DiseasesAutoimmunityDrug Delivery SystemsExtracellular MatrixHumansFibronectinsExtracellular matrixImmunologyMultiple sclerosisRheumatoid arthritisSystemic sclerosisType 1 diabetes

Identifiers

PMID38588958
PMCPMC11111362
OpenAlexW4394008876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.