Evidence map›Paper›PMID 38588922›Full record

ArticleJournal of neuroscience methods2024

An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys.

Lucy Liang, Isabela Zimmermann Rollin, Aydin Alikaya, Jonathan C Ho, Tales Santini, Andreea C Bostan, Helen N Schwerdt, William R Stauffer, Tamer S Ibrahim, Elvira Pirondini and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. An open access resource for marmoset neuroscientific apparatus.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lucy LiangRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA.
Isabela Zimmermann RollinDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Aydin AlikayaDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Jonathan C HoRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Tales SantiniDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Andreea C BostanDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Helen N SchwerdtDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
William R StaufferDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Tamer S IbrahimDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; University of Pittsburgh, Psychiatry, Pittsburgh, PA, USA; University of Pittsburgh, Radiology, Pittsburgh, PA, USA.
Elvira PirondiniRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Center for Neural Basis of Cognition, Pittsburgh, PA, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
David J SchaefferDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. Electronic address: dschaeff@pitt.edu.
University of Pittsburgh · USResearch Network (United States) · USCenter for the Neural Basis of Cognition · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Viral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Smriti Mehra · 2012 to 2026
$35.6M
Cell type specific AAVs to study reward and cognitionUF1MH130881 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BYRNE, LEAH, PFENNING, ANDREAS ROBERT · 2022 to 2022
$6.9M
High Performance Imaging for Assessment of Small Vessel Disease in Older Adults with DepressionR01MH111265 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, IBRAHIM, TAMER S · 2016 to 2020
$3.6M
Deep brain stimulation of the motor thalamus to improve cortico-spinal control of muscles after strokeR01NS131428 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jorge Alvaro Gonzalez-Martinez, Elvira Pirondini · 2024 to 2026
$1.8M
A novel method for transient and repeatable axonal tracing in developing marmosetsR21NS125372 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHAEFFER, DAVID J · 2022 to 2022
$428k
NIH HHS P51 OD011133NIH HHS U42 OD010442NIMH NIH HHS R01 MH111265NIMH NIH HHS UF1 MH130881NINDS NIH HHS R01 NS131428NINDS NIH HHS R21 NS125372
6 · The paper itself

Abstract

backgroundHigh-precision neurosurgical targeting in nonhuman primates (NHPs) often requires presurgical anatomical mapping with noninvasive neuroimaging techniques (MRI, CT, PET), allowing for translation of individual anatomical coordinates to surgical stereotaxic apparatus. Given the varied tissue contrasts that these imaging techniques produce, precise alignment of imaging-based coordinates to surgical apparatus can be cumbersome. MRI-compatible stereotaxis with radiopaque fiducial markers offer a straight-forward and reliable solution, but existing commercial options do not fit in conformal head coils that maximize imaging quality. NEW

methodWe developed a compact MRI-compatible stereotaxis suitable for a variety of NHP species (Macaca mulatta, Macaca fascicularis, and Cebus apella) that allows multimodal alignment through technique-specific fiducial markers. COMPARISON WITH EXISTING

methodsWith the express purpose of compatibility with clinically available MRI, CT, and PET systems, the frame is no larger than a human head, while allowing for imaging NHPs in the supinated position. This design requires no marker implantation, special software, or additional knowledge other than the operation of a common large animal stereotaxis.

resultsWe demonstrated the applicability of this 3D-printable apparatus across a diverse set of experiments requiring presurgical planning: 1) We demonstrate the accuracy of the fiducial system through a within-MRI cannula insertion and subcortical injection of a viral vector. 2) We also demonstrated accuracy of multimodal (MRI and CT) alignment and coordinate transfer to guide a surgical robot electrode implantation for deep-brain electrophysiology.

conclusionsThe computer-aided design files and engineering drawings are publicly available, with the modular design allowing for low cost and manageable manufacturing.

Indexed as

Brain MappingCebusMagnetic Resonance ImagingAnimalsBrainFiducial MarkersMacaca mulattaMaleMultimodal ImagingStereotaxic TechniquesBrainCapuchinComputerized tomographyMacaqueMagnetic resonance imagingPositron emission tomographyStereotaxic frame

Identifiers

PMID38588922
PMCPMC11127775
OpenAlexW4394014279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.