Evidence map›Paper›PMID 38588427›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling.

Yen-Ching Chang, Yuan Gao, Joo Yeun Lee, Yi-Jheng Peng, Jennifer Langen, Karen T Chang

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
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  9. Article
  10. Turning garbage into gold: Autophagy in synaptic function.Current opinion in neurobiology · 2025
    Review
  11. Lysosomes' fallback strategies: more than just survival or death.Frontiers in cell and developmental biology · 2025
    Review
  12. Review
  13. microPublication biology · 2025
    Article
  14. Canonical and noncanonical autophagy: involvement in Parkinson's disease.Frontiers in cell and developmental biology · 2025
    Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yen-Ching Chang *Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0003-0982-7840
Yuan Gao *Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Joo Yeun LeeZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0001-6616-5594
Yi-Jheng PengZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0009-0007-2344-8990
Jennifer LangenZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0003-4427-1489
Karen T ChangZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
University of Southern California · US

Funding

Role of DYRK1A/MNB in Synaptic growth and functionR01NS080946 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAREN T CHANG · 2013 to 2026
$5.0M
Molecular mechanisms underlying activity-induced synaptic remodelingR01NS102260 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHANG, KAREN T · 2018 to 2022
$2.2M
NINDS NIH HHS R01 NS080946NINDS NIH HHS R01 NS102260
6 · The paper itself

Abstract

The ability of neurons to rapidly remodel their synaptic structure and strength in response to neuronal activity is highly conserved across species and crucial for complex brain functions. However, mechanisms required to elicit and coordinate the acute, activity-dependent structural changes across synapses are not well understood, as neurodevelopment and structural plasticity are tightly linked. Here, using an RNAi screen in

Indexed as

Drosophila ProteinsNeuromuscular JunctionAnimalsAutophagyDrosophilaGTP PhosphohydrolasesHumansNeuronal PlasticityNeuronsSynapsesSynaptic TransmissionDrosophila ProteinsGTP PhosphohydrolasesRab8 protein, DrosophilaautophagyDrosophilaneuromuscular junctionsynaptic plasticitysynaptic remodeling

Identifiers

PMID38588427
PMCPMC11032469
OpenAlexW4394581546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.