Evidence map›Paper›PMID 38588130›Full record

ArticleJournal of neurotrauma2024

Designer Receptor Exclusively Activated by Designer Drug (DREADD)-Mediated Activation of the Periaqueductal Gray Restores Nociceptive Descending Inhibition After Traumatic Brain Injury in Rats.

Karen-Amanda Irvine, Xiao-You Shi, Adam R Ferguson, J David Clark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen-Amanda IrvineDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Xiao-You ShiDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Adam R FergusonBrain and Spinal Injury Center, Department of Neurosurgery, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
J David ClarkDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.

Funding

Tools for Common Data Element Adoption in the Pan-Neurotrauma Data Commons (PANORAUMA)U24NS122732 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADAM R FERGUSON, Jeffrey S. Grethe · 2021 to 2026
$5.0M
Translational Outcomes Project: Visualizing Syndromic Information and Outcomes for Neurotrauma (TOP-VISION)UH3NS106899 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2020 to 2022
$1.2M
Traumatic Brain Injury and Endogenous Pain ModulationI01RX001776 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI CLARK, DAVID J. · 2016 to 2025
–
Leveraging data-science for discovery in chronic TBII01RX002787 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI FERGUSON, ADAM R · 2018 to 2025
–
NINDS NIH HHS U24 NS122732NINDS NIH HHS UH3 NS106899RRD VA I01 RX001776RRD VA I01 RX002787
6 · The paper itself

Abstract

Traumatic brain injury (TBI) patients frequently experience chronic pain that can enhance their suffering and significantly impair rehabilitative efforts. Clinical studies suggest that damage to the periaqueductal gray matter (PAG) following TBI, a principal center involved in endogenous pain control, may underlie the development of chronic pain. We hypothesized that TBI would diminish the usual pain control functions of the PAG, but that directly stimulating this center using a chemogenetic approach would restore descending pain modulation. We used a well-characterized lateral fluid percussion model (1.3 ± 0.1 atm) of TBI in male rats (

Indexed as

Brain Injuries, TraumaticDesigner DrugsPeriaqueductal GrayRats, Sprague-DawleyAnimalsMaleNociceptionRatsDesigner Drugschronic painopioidsperiaqueductal grayserotonintraumatic brain injury

Identifiers

PMID38588130
PMCPMC11386998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.