ArticlePlant physiology2024
The CELL NUMBER REGULATOR FW2.2 protein regulates cell-to-cell communication in tomato by modulating callose deposition at plasmodesmata.
Article in Plant physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrated Meta-QTL analysis and transcriptomic profiling reveal genomic regions for fruit quality, abiotic and biotic stress resilience in cucumber (Cucumis sativus L.).BMC plant biology · 2026Pooled it
- Dual Color tau-STED Super Resolution Microscopy inBio-protocol · 2026Article
- Article
- Plasmodesmata wall biomechanics: challenges and opportunities.Journal of experimental botany · 2026Review
- Cell-to-cell connectivity: a future target for crop improvement.Journal of experimental botany · 2026Review
- The study of plasmodesmal biology using proximity labeling technologies.Journal of experimental botany · 2026Review
- The CELL NUMBER REGULATOR SlFWL5 protein regulates aerial vegetative growth in tomato, by promoting cell expansion.Journal of experimental botany · 2026Article
- Transcriptomic changes associated with heat-induced susceptibility in wheat plants to Hessian fly (Diptera: Cecidomyiidae).Frontiers in plant science · 2026Article
- Application of 4-CPA or ethanol enhances plant growth and fruit quality of phyA mutant under heat stress.Scientific reports · 2025Article
- Article
- Loss-of-Function of Two PD-Associated Proteins Confers Resistance to Rice Stripe Virus.Molecular plant pathology · 2025Article
- Tomato FW2.2/CNR might regulate fruit size via plasmodesmata callose deposition.Plant physiology · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
FW2.2 (standing for FRUIT WEIGHT 2.2), the founding member of the CELL NUMBER REGULATOR (CNR) gene family, was the first cloned gene underlying a quantitative trait locus (QTL) governing fruit size and weight in tomato (Solanum lycopersicum). However, despite this discovery over 20 yr ago, the molecular mechanisms by which FW2.2 negatively regulates cell division during fruit growth remain undeciphered. In the present study, we confirmed that FW2.2 is a membrane-anchored protein whose N- and C-terminal ends face the apoplast. We unexpectedly found that FW2.2 is located at plasmodesmata (PD). FW2.2 participates in the spatiotemporal regulation of callose deposition at PD and belongs to a protein complex which encompasses callose synthases. These results suggest that FW2.2 has a regulatory role in cell-to-cell communication by modulating PD transport capacity and trafficking of signaling molecules during fruit development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.