ArticleLiver international : official journal of the International Association for the Study of the Liver2024
Macrophage activation markers are associated with infection and mortality in patients with acute liver failure.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Early peripheral monocyte dynamics are associated with 28-day mortality in acute liver failure: an exploratory longitudinal cohort study.Frontiers in medicine · 2026Article
- Adrenomedullin as an Immunomodulator of CD14Journal of clinical and translational hepatology · 2025Article
- Sepsis in liver failure patients: Diagnostic challenges and recent advancements.World journal of critical care medicine · 2025Review
- Plasma exchange to treat liver failure: The field expands.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Article
- Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis.Frontiers in immunology · 2025Article
- Macrophage activation markers are associated with infection and mortality in patients with acute liver failure.Liver international : official journal of the International Association for the Study of the Liver · 2024Article
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Authors and funding
17 authors.
Funding
Abstract
BACKGROUND AND
aimsAcute liver failure is a multisystem disorder with a high mortality and frequent need for emergency liver transplantation. Following massive innate immune system activation, soluble markers of macrophage activation are released during liver damage and their association with disease severity and prognosis requires exploration.
methodsPatients ALF from the United States Acute Liver Failure Study Group (USALFSG, n = 224) and King's College Hospital (n = 40) together with healthy controls (HC, n = 50) were recruited. Serum from early (Days 1-3) and late (>Day 3) time points were analysed for MAMs by enzyme-linked immunosorbent assay correlated to markers of illness severity and 21-day spontaneous survival. Surface expression phenotyping was performed via Flow Cytometry on CD14
resultsAll MAMs serum concentrations were significantly higher in ALF compared to controls (p < .0001). sCD206 concentration was higher in early and late stages of the disease in patients with bacteraemia (p = .002) and infection in general (p = .006). In MELD-adjusted multivariate modelling, sCD206 and sCD163 were independently associated with mortality. CD14
conclusionssCD206 is increased in serum of ALF patients with infections and poor outcome and is upregulated on CD14
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