ArticleNeuropsychopharmacology reports2024
Vortioxetine-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report.
Article in Neuropsychopharmacology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Vortioxetine-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report.Neuropsychopharmacology reports · 2024Article
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6 authors.
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Abstract
backgroundVortioxetine, known for its efficacy in treating depression through its effects on various neurotransmitters, has not been previously reported to induce syndrome of inappropriate secretion of antidiuretic hormone (SIADH). CASE PRESENTATION: This case report describes a 74-year-old man with major depressive disorder who developed SIADH 1 week after starting treatment with vortioxetine. SIADH is characterized by symptoms such as headache, nausea, disorientation, and seizures, stemming from hyponatremia (123 mEq/L), without dehydration or edema. Vortioxetine was discontinued, and an alternative drug, mianserin, was initiated. The patient was restricted from drinking water due to hyponatremia. The serum Na concentration improved over time to within the normal range by the second week after admission.
conclusionThis is the first case report of vortioxetine-induced SIADH.
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