Evidence map›Paper›PMID 38587980›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2024

Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI.

Patrick Albers, Jacob Bennett, Moira Evans, Ella St Martin, Betty Wang, Stacey Broomfield, Anaïs Medina Martín, Wendy Tu, Christopher Fung, Adam Kinnaird

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07386171 (Evaluating Micro-Ultrasound as a Supplemental Imaging Modality for Clinically Significant Prostate Cancer Detection in Men With Negative or Stable Multiparametric MRI on Active Surveillance or at Diagnosis), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07386171 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluating Micro-Ultrasound as a Supplemental Imaging Modality for Clinically Significant Prostate Cancer Detection in Men With Negative or Stable Multiparametric MRI on Active Surveillance or at Diagnosis

TypeinterventionalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2026 to 2027Enrolled90ConditionsProstate Cancer, Active Surveillance for Prostate Cancer, Imaging TechniquesArmsMicro-Ultrasound (mUS)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Micro-ultrasound for prostate cancer.Nature reviews. Urology · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patrick AlbersDivision of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Jacob BennettDivision of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Moira EvansDivision of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Ella St MartinDivision of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Betty WangDivision of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Stacey BroomfieldDivision of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Anaïs Medina MartínAlberta Prostate Cancer Research Initiative (APCaRI), Edmonton, AB, Canada.
Wendy TuDepartment of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
Christopher FungDepartment of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada.
Adam KinnairdDivision of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging technology that could visualize csPCa that is missed by MRI.

methodsThis retrospective review included 1011 consecutive patients biopsied between September 2021 and July 2023 in Alberta, Canada. Among them were 103 biopsy-naive patients with negative MRI (Prostate Imaging Reporting & Data System [PI-RADS] ≤2) undergoing microUS-informed prostate biopsy (n=56) scored using Prostate Risk Identification Using Micro-ultrasound (PRI-MUS) or standard transrectal ultrasound prostate biopsy (n=47). The primary outcome was detection rate of csPCa stratified by biopsy technique and PRI-MUS score.

resultsMicroUS biopsy identified csPCa in 14/56 (25%) compared to standard biopsy in 8/47 (17%) (p=0.33). Patients with lesions PRI-MUS ≥3 had csPCa detected at a higher rate compared to patients with PRI-MUS ≤2 (42% vs. 16%, p=0.03). The csPCa detection rate was significantly different comparing patients with prostate-specific antigen (PSA) density <0.15 and PRI-MUS ≤2 compared to patients with PSA density ≥0.15 and PRI-MUS ≥3 (14% vs. 60%, p=0.02).

conclusionsMicroUS may aid in the detection of csPCa for patients with negative MRI.

Identifiers

PMID38587980
PMCPMC11230689

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.