Evidence map›Paper›PMID 38587710›Full record

ArticleMycotoxin research2024

Estrogenic, androgenic, and genotoxic activities of zearalenone and deoxynivalenol in in vitro bioassays including exogenous metabolic activation.

Maria Yu, Agneta Oskarsson, Jan Alexander, Johan Lundqvist

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mycotoxin research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Maria YuDepartment of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, SE-750 07, Uppsala, Sweden. maria.yu@slu.se.ORCID http://orcid.org/0000-0002-0635-2504
Agneta OskarssonDepartment of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, SE-750 07, Uppsala, Sweden.
Jan AlexanderNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, NO-0213, Oslo, Norway.
Johan LundqvistDepartment of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, SE-750 07, Uppsala, Sweden.
Swedish University of Agricultural Sciences · SENorwegian Institute of Public Health · NO

Funding

Svenska Forskningsrådet Formas 2018-02256Svenska Forskningsrådet Formas 2019-02043Svenska Forskningsrådet Formas grants number 2018-00386
6 · The paper itself

Abstract

Zearalenone (ZEN) and deoxynivalenol (DON) and their derivatives are well-known mycotoxins, which can occur not only in crops but also in water bodies, including drinking water sources. In vitro bioassays can be used to detect biological effects of hazardous compounds in water. To this, when studying biological effects and toxicity in vitro, metabolism is important to consider. In this study, ZEN, α-zearalenol (α-ZEL), DON, 3-acetyl DON, and 15-acetyl DON were evaluated in vitro for hormone receptor-mediated effects (estrogen receptor [ER] and androgen receptor [AR]) and genotoxicity (micronucleus assay) in the presence of an exogenous metabolic activation system (MAS). The ER bioassay proved to be a highly sensitive method to detect low concentrations of the ZEN compounds (EC

Indexed as

Biological AssayTrichothecenesZearalenoneAndrogensEstrogensHumansMicronucleus TestsMutagensReceptors, AndrogenReceptors, EstrogenAndrogensdeoxynivalenolEstrogensMutagensReceptors, AndrogenReceptors, EstrogenTrichothecenesZearalenoneDeoxynivalenolEffect-based methodsEndocrine receptorsIn vitro bioassaysMetabolismMicronuclei formationZearalenone

Identifiers

PMID38587710
PMCPMC11258189
OpenAlexW4394567005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.