Evidence map›Paper›PMID 38587590›Full record

ArticleJournal of microbiology (Seoul, Korea)2024

Hydroxychloroquine an Antimalarial Drug, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Multitargeting.

Sargun Tushar Basrani, Tanjila Chandsaheb Gavandi, Shivani Balasaheb Patil, Nandkumar Subhash Kadam, Dhairyasheel Vasantrao Yadav, Sayali Ashok Chougule, Sankunny Mohan Karuppayil, Ashwini Khanderao Jadhav

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sargun Tushar BasraniDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India.
Tanjila Chandsaheb GavandiDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India.
Shivani Balasaheb PatilDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India.
Nandkumar Subhash KadamDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India.
Dhairyasheel Vasantrao YadavDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India.
Sayali Ashok ChouguleDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India.
Sankunny Mohan KaruppayilDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India.
Ashwini Khanderao JadhavDepartment of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kadamwadi, Kolhapur, Maharashtra, 416003, India. ashujadhav09@gmail.com.ORCID http://orcid.org/0000-0003-4204-301X

Funding

D.Y. Patil Education Society Institution Deemed to be University Kolhapur DYPES/DU/R&D/2022/2349
6 · The paper itself

Abstract

Candida albicans is the primary etiological agent associated with candidiasis in humans. Unrestricted growth of C. albicans can progress to systemic infections in the worst situation. This study investigates the antifungal activity of Hydroxychloroquine (HCQ) and mode of action against C. albicans. HCQ inhibited the planktonic growth and yeast to hyphal form morphogenesis of C. albicans significantly at 0.5 mg/ml concentration. The minimum inhibitory concentrations (MIC

Indexed as

Antifungal AgentsBiofilmsCandida albicansCandidiasisHydroxychloroquineMicrobial Sensitivity TestsAnimalsAntimalarialsCell CycleErgosterolFungal ProteinsGene Expression Regulation, FungalHyphaeMiceReactive Oxygen SpeciesAntifungal AgentsAntimalarialsErgosterolFungal ProteinsHydroxychloroquineReactive Oxygen SpeciesCell cycleErgosterolGene expressionHCQIn vivoROS productionVirulence factors

Identifiers

PMID38587590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.