Evidence map›Paper›PMID 38587438›Full record

ArticleCirculation. Heart failure2024

Early Serial Assessment of Aggregate Vasoactive Support and Mortality in Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network Registry.

Siddharth M Patel, David D Berg, Erin A Bohula, Vivian M Baird-Zars, Gregory W Barsness, Sunit-Preet Chaudhry, Meshe D Chonde, Howard A Cooper, Curtis Ginder, Jacob C Jentzer and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Siddharth M PatelLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.P., D.D.B., E.A.B., V.M.B.-Z., C.G., J.-G.P., D.A.M.).
David D BergLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.P., D.D.B., E.A.B., V.M.B.-Z., C.G., J.-G.P., D.A.M.).ORCID 0000-0002-0366-5492
Erin A BohulaLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.P., D.D.B., E.A.B., V.M.B.-Z., C.G., J.-G.P., D.A.M.).ORCID 0000-0002-5559-8172
Vivian M Baird-ZarsLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.P., D.D.B., E.A.B., V.M.B.-Z., C.G., J.-G.P., D.A.M.).
Gregory W BarsnessDepartment of Cardiovascular Medicine, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN (G.W.B., J.C.J.).ORCID 0000-0002-6353-6780
Sunit-Preet ChaudhryDepartment of Cardiology, St Vincent Heart Center, Indianapolis, IN (S.-P.C.).ORCID 0000-0002-2788-7532
Meshe D ChondeDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (M.D.C.).ORCID 0000-0002-9829-7898
Howard A CooperDepartment of Cardiology, Westchester Medical Center, Valhalla, NY (H.A.C.).
Curtis GinderLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.P., D.D.B., E.A.B., V.M.B.-Z., C.G., J.-G.P., D.A.M.).ORCID 0000-0001-8507-9624
Jacob C JentzerDepartment of Cardiovascular Medicine, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN (G.W.B., J.C.J.).
Michael C KontosDivision of Cardiology, Department of Medicine, Virginia Commonwealth University, Richmond (M.C.K.).
P Elliott MillerSection of Cardiovascular Medicine, Yale University, New Haven, CT (P.E.M.).ORCID 0000-0002-0595-1492
L Kristin NewbyDivision of Cardiology and Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (L.K.N.).ORCID 0000-0002-6394-8187
Connor G O'BrienDivision of Cardiology, Department of Medicine, University of California San Francisco (C.G.O.B.).ORCID 0000-0002-2325-8317
Jeong-Gun ParkLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.P., D.D.B., E.A.B., V.M.B.-Z., C.G., J.-G.P., D.A.M.).ORCID 0000-0003-4615-1747
Matthew J PierceDepartment of Cardiology, Northwell Health, Zucker School of Medicine, New Hyde Park, NY (M.J.P.).ORCID 0009-0000-6408-1821
Barbara A PisaniSection of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC (B.A.P.).ORCID 0000-0002-8148-2317
Brian J PotterCardiology Service, Department of Medicine, Centre Hospitalier de l'Université de Montréal Research Center and Cardiovascular Center, Quebec, QC, Canada (B.J.P.).ORCID 0000-0002-0316-9026
Kevin S ShahDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City (K.S.S.).
Jeffrey J TeutebergDivision of Cardiovascular Medicine, Stanford University School of Medicine, CA (J.J.T.).ORCID 0000-0002-8342-3222
Jason N KatzDivision of Cardiovascular Medicine, Department of Medicine, New York University School of Medicine, New York (J.N.K.).ORCID 0000-0002-3460-5169
Sean van DiepenDepartment of Critical Care Medicine and Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada (S.v.D.).ORCID 0000-0002-6688-828X
David A MorrowLevine Cardiac Intensive Care Unit, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.M.P., D.D.B., E.A.B., V.M.B.-Z., C.G., J.-G.P., D.A.M.).ORCID 0000-0002-9589-5382

Funding

TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0M
NHLBI NIH HHS T32 HL007604
6 · The paper itself

Abstract

backgroundAssociations of early changes in vasoactive support with cardiogenic shock (CS) mortality remain incompletely defined.

methodsThe Critical Care Cardiology Trials Network is a multicenter registry of cardiac intensive care units. Patients admitted with CS (2018-2023) had vasoactive dosing assessed at 4 and 24 hours from cardiac intensive care unit admission and quantified by the vasoactive-inotropic score (VIS). Prognostic associations of VIS at both time points, as well as change in VIS from 4 to 24 hours, were examined. Interaction testing was performed based on mechanical circulatory support status.

resultsAmong 3665 patients, 82% had a change in VIS <10, with 7% and 11% having a ≥10-point increase and decrease from 4 to 24 hours, respectively. The 4 and 24-hour VIS were each associated with cardiac intensive care unit mortality (13%-45% and 11%-73% for VIS <10 to ≥40, respectively;

conclusionsEarly changes in the magnitude of vasoactive support in CS are associated with a gradient of risk for mortality. These data suggest that early VIS trajectory may improve CS prognostication, with the potential to be leveraged for clinical decision-making and research applications in CS.

Indexed as

RegistriesShock, CardiogenicAgedCritical CareFemaleHospital MortalityHumansMaleMiddle AgedPrognosisRisk AssessmentTime Factorscardiogenic shockcardiotonic agentsheart failuremortalityvasoconstrictor agents

Identifiers

PMID38587438
PMCPMC12684181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.