Evidence map›Paper›PMID 38587426›Full record

ArticlemBio2024

Recombinational exchange of M-fibril and T-pilus genes generates extensive cell surface diversity in the global group A

Debra E Bessen, Bernard W Beall, Andrew Hayes, Weihua Huang, Jeanne M DiChiara, Srinivasan Velusamy, Hervé Tettelin, Keith A Jolley, John T Fallon, Sopio Chochua and 6 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The group AInfection and immunity · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Debra E BessenDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York, USA.ORCID 0000-0002-8061-7750
Bernard W BeallRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0001-5315-1070
Andrew HayesDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Weihua HuangDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York, USA.ORCID 0000-0003-1176-3719
Jeanne M DiChiaraDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York, USA.ORCID 0009-0005-1256-7180
Srinivasan VelusamyRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0001-6864-9699
Hervé TettelinDepartment of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Keith A JolleyDepartment of Biology, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-0751-0287
John T FallonDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York, USA.ORCID 0000-0002-7677-4868
Sopio ChochuaRespiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.ORCID 0000-0001-8222-7353
Mosaed S A AlobaidallahDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, New York, USA.ORCID 0009-0003-9108-4755
Charlie HiggsDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Timothy C BarnettThe Marshall Centre for Infectious Diseases Research and Training, School of Biomedical Sciences, University of Western Australia, Nedlands, Australia.ORCID 0000-0002-3346-5117
John T SteemsonSchool of Biological Sciences, The University of Auckland, Auckland, New Zealand.
Thomas ProftSchool of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.ORCID 0000-0002-9275-5042
Mark R DaviesEagle Global Scientific, LLC, Atlanta, Georgia, USA.ORCID 0000-0001-6141-5179

Funding

Protective antibody in streptococcal infection modelsR01AI173565 · NIAID · NEW YORK MEDICAL COLLEGE · PI Debra E BESSEN · 2023 to 2026
$1.8M
Macrolide resistance transfer in Streptococcus pyogenesR21AI156226 · NIAID · NEW YORK MEDICAL COLLEGE · PI BESSEN, DEBRA E · 2021 to 2022
$461k
Pilin Genotyping for Group A StreptococciR03AI148983 · NIAID · NEW YORK MEDICAL COLLEGE · PI BESSEN, DEBRA E · 2020 to 2021
$161k
NIAID NIH HHS R01 AI173565NIAID NIH HHS R03 AI148983NIAID NIH HHS R21 AI156226Wellcome TrustWellcome Trust Biomedical Resource 218205/Z/19/Z
6 · The paper itself

Abstract

Among genes present in all group A streptococci (GAS), those encoding M-fibril and T-pilus proteins display the highest levels of sequence diversity, giving rise to the two primary serological typing schemes historically used to define strain. A new genotyping scheme for the pilin adhesin and backbone genes is developed and, when combined with

Indexed as

Genetic VariationGenotypeStreptococcus pyogenesAntigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsFimbriae, BacterialFimbriae ProteinsGene Transfer, HorizontalHumansImpetigoPharyngitisRecombination, GeneticStreptococcal InfectionsAntigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsFimbriae Proteinsstreptococcal M proteincell surface proteinsgenotypinggroup A streptococcusmolecular epidemiologypilipopulation biology

Identifiers

PMID38587426
PMCPMC11078000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.