Evidence map›Paper›PMID 38587425›Full record

ArticlemBio2024

Optimization of the antifungal properties of the bacterial peptide EntV by variant analysis.

Shantanu Guha, Shane A Cristy, Giuseppe Buda De Cesare, Melissa R Cruz, Michael C Lorenz, Danielle A Garsin

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Microbiology spectrum · 2026
    Article
  4. Article
  5. Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shantanu GuhaDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Shane A CristyDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0001-7316-9331
Giuseppe Buda De CesareDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Melissa R CruzDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0003-2399-3343
Michael C LorenzDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-7881-8027
Danielle A GarsinDepartment of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-6551-2600

Funding

Molecular Basis of Infectious Diseases Training GrantT32AI055449 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2005 to 2025
$2.6M
Inhibition of Candida Virulence and Biofilm Formation by a Bacterial PeptideR01DE027608 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A, LORENZ, MICHAEL C · 2018 to 2022
$2.5M
Mechanism of Fungal Virulence Inhibition by a Bacterial PeptideR01AI183606 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Danielle A Garsin, Michael C Lorenz · 2024 to 2026
$2.2M
Texas Medical Center Training Program in Antimicrobial ResistanceT32AI141349 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2019 to 2023
$1.3M
NIAID NIH HHS R01 AI183606NIAID NIH HHS T32 AI055449NIAID NIH HHS T32 AI141349NIDCR NIH HHS R01 DE027608
6 · The paper itself

Abstract

Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by IMPORTANCE: Since the early 1980s, the incidence of disseminated life-threatening fungal infections has been on the rise. Worldwide,

Indexed as

Antifungal AgentsBiofilmsCaenorhabditis elegansCandida albicansCandidiasisEnterococcus faecalisMicrobial Sensitivity TestsAnimalsBacterial ProteinsDisease Models, AnimalMicePeptidesAntifungal AgentsBacterial ProteinsPeptidesantifungal therapyantimicrobial peptidesCandidaCryptococcus

Identifiers

PMID38587425
PMCPMC11077972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.