Evidence map›Paper›PMID 38587411›Full record

ArticleMicrobiology spectrum2024

A highly conserved tRNA modification contributes to

Bettina Böttcher, Sandra D Kienast, Johannes Leufken, Cristian Eggers, Puneet Sharma, Christine M Leufken, Bianka Morgner, Hannes C A Drexler, Daniela Schulz, Stefanie Allert and 4 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. RNA modification is the mark and strategy for host-microbe interactions.Cellular and molecular life sciences : CMLS · 2025
    Review
  6. Article
  7. Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Bettina BöttcherDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Sandra D KienastMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Johannes LeufkenMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Cristian EggersMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Puneet SharmaMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Christine M LeufkenMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Bianka MorgnerDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Hannes C A DrexlerBioanalytical Mass Spectrometry Unit, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Daniela SchulzDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Stefanie AllertDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Ilse D JacobsenResearch Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.
Slavena VylkovaSeptomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.ORCID 0000-0002-0051-4664
Sebastian A LeidelMax Planck Research Group for RNA Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Sascha BrunkeDepartment of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany.ORCID 0000-0001-7740-4570
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversity of Bern · CHMax Planck Institute for Molecular Biomedicine · DE

Funding

Bundesministerium für Bildung und Forschung (BMBF) 03Z22JN11Deutsche Forschungsgemeinschaft (DFG) SPP2225Deutsche Forschungsgemeinschaft (DFG) STA1147/1-1Deutsche Forschungsgemeinschaft (DFG) TRR124EC | European Research Council (ERC) ERC-2012-StG 310489-tRNAmodi
6 · The paper itself

Abstract

tRNA modifications play important roles in maintaining translation accuracy in all domains of life. Disruptions in the tRNA modification machinery, especially of the anticodon stem loop, can be lethal for many bacteria and lead to a broad range of phenotypes in baker's yeast. Very little is known about the function of tRNA modifications in host-pathogen interactions, where rapidly changing environments and stresses require fast adaptations. We found that two closely related fungal pathogens of humans, the highly pathogenic

Indexed as

Candida albicansCandidiasisFungal ProteinsHyphaeRNA, TransferAnimalsCandidaEpithelial CellsHost-Pathogen InteractionsHumansMiceVirulenceFungal ProteinsRNA, TransferCandida albicanshost-pathogen interactionstRNA modificationvirulence regulation

Identifiers

PMID38587411
PMCPMC11064501
OpenAlexW4394568783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.