Evidence map›Paper›PMID 38587021›Full record

ArticlePsychological medicine2024

Early auditory processing abnormalities alter individual learning trajectories and sensitivity to computerized cognitive training in schizophrenia.

Juan L Molina, Yash B Joshi, John A Nungaray, Joyce Sprock, Mouna Attarha, Bruno Biagianti, Michael L Thomas, Neal R Swerdlow, Gregory A Light

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan L MolinaDepartment of Psychiatry, University of California, San Diego, CA, USA.
Yash B JoshiDepartment of Psychiatry, University of California, San Diego, CA, USA.
John A NungarayDepartment of Psychiatry, University of California, San Diego, CA, USA.
Joyce SprockDepartment of Psychiatry, University of California, San Diego, CA, USA.
Mouna AttarhaDepartment of R&D, Posit Science Corporation, San Francisco, CA, USA.
Bruno BiagiantiDepartment of Psychology, University of Milano-Bicocca, Milan, Italy.
Michael L ThomasDepartment of Psychology, Colorado State University, Fort Collins, CO, USA.
Neal R SwerdlowDepartment of Psychiatry, University of California, San Diego, CA, USA.
Gregory A LightDepartment of Psychiatry, University of California, San Diego, CA, USA.

Funding

The Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0M
SENSORY GATING &HABITUATION IN SCHIZOPHRENIAR01MH042228 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 1987 to 2015
$6.5M
The Genetics of Endophenotypes and SchizophreniaR01MH065578 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2003 to 2013
$4.2M
The Genetics of Endophenotypes and SchizophreniaR01MH065554 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIEVER, LARRY J · 2003 to 2013
$4.1M
Genetics of Endophenotypes and SchizophreniaR01MH065558 · NIMH · UNIVERSITY OF WASHINGTON · PI TSUANG, DEBBY WEN · 2003 to 2013
$3.7M
The Genetics of Endophenotypes and SchizophreniaR01MH065707 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F. · 2003 to 2013
$3.6M
Psychiatry Research Residency Training TrackR25MH101072 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEAL R SWERDLOW · 2013 to 2026
$2.8M
Pharmacologic augmentation of targeted cognitive training in schizophreniaR33MH123603 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 2020 to 2022
$2.3M
Memantine augmentation of cognitive training in schizophreniaR33MH125114 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIGHT, GREGORY A · 2021 to 2023
$2.2M
Biomarker Predictors of Memantine Sensitivity in patients with Alzheimer's DiseaseR01AG059640 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 2018 to 2022
$2.0M
Pathway(s) From Genes to Functional Deficits of Schizophrenia PatientsR01MH079777 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIGHT, GREGORY A · 2007 to 2010
$1.4M
Neuroimaging and Neurocognitive Computerized Adaptive Testing in SchizophreniaK23MH102420 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMAS, MICHAEL L · 2014 to 2018
$815k
Brain and Behavior Research Foundation 28927NIA NIH HHS AG059640NIA NIH HHS R01 AG059640NIMH NIH HHS K23 MH102420NIMH NIH HHS MH123603NIMH NIH HHS R01 MH042228NIMH NIH HHS R01 MH065554NIMH NIH HHS R01 MH065558NIMH NIH HHS R01 MH065571NIMH NIH HHS R01 MH065578NIMH NIH HHS R01 MH065707NIMH NIH HHS R01 MH079777NIMH NIH HHS R25 MH101072NIMH NIH HHS R33 MH123603NIMH NIH HHS R33 MH125114RRD VA IK1 RX003683RRD VA IK2 RX003395RRD VA IK2 RX004570
6 · The paper itself

Abstract

backgroundAuditory system plasticity is a promising target for neuromodulation, cognitive rehabilitation and therapeutic development in schizophrenia (SZ). Auditory-based targeted cognitive training (TCT) is a 'bottom up' intervention designed to enhance the speed and accuracy of auditory information processing, which has been shown to improve neurocognition in certain SZ patients. However, the dynamics of TCT learning as a function of training exercises and their impact on neurocognitive functioning and therapeutic outcomes are unknown.

methodsForty subjects (SZ,

resultsSZ patients were deficient in APS at baseline (

conclusionsTCT learning metrics may have prognostic utility and aid in the prospective identification of individuals likely to benefit from TCT. Future experimental medicine studies may advance predictive algorithms that enhance TCT-related clinical, cognitive and functional outcomes.

Indexed as

SchizophreniaAdultAuditory PerceptionCognitive Behavioral TherapyCognitive RemediationCognitive TrainingFemaleHumansLearningMaleMiddle AgedTherapy, Computer-AssistedYoung Adultcognitive rehabilitationcognitive trainingearly auditory processingschizophrenia

Identifiers

PMID38587021
PMCPMC13399390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.