Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
Yike ZhuCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0002-5761-0243
Matthew Ackers-JohnsonCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0002-1308-6785
Muthu K ShanmugamCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0002-8314-9227
Leroy Sivappiragasam PakkiriCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0003-2768-0918
Chester Lee DrumCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0001-6327-4584
Johnny KimMax Planck Institute for Heart and Lung Research, Bad Nauheim, Germany (C.Y., J.K.).ORCID 0000-0002-5226-5460
Wyatt G PaltzerDepartment of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison (W.G.P., A.I.M.).ORCID 0000-0002-9142-4217
Ahmed I MahmoudDepartment of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison (W.G.P., A.I.M.).ORCID 0000-0003-1528-7393
Wilson Lek Wen TanCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0002-5054-8512
Mick Chang Jie LeeCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0001-6673-9391
Jianming JiangCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0003-3251-2716
Danh Anh Tuan LuuCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).
Shi Ling NgCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0002-6107-5634
Peter Yi Qing LiCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0002-5655-9191
Anhui WangDepartment of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Centre (W.A., Q.R.), Peking University, China.
Rong QiDepartment of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Centre (W.A., Q.R.), Peking University, China.ORCID 0000-0002-0627-9968
Gabriel Jing Xiang OngCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0009-0000-0309-5146
Timothy Yu NgCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0009-0006-0214-3189
Jody J HaighCancerCare Manitoba Research Institute, Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada (J.J.H.).ORCID 0000-0002-7319-8922
Zenia TiangCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0003-1182-0023
A Mark RichardsCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).ORCID 0000-0002-2023-8177
Roger S Y FooCardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., R.S.Y.F.).
L-3 Communications (United States) · USMax Planck Institute for Heart and Lung Research · DEPeking University · CNUniversity of Wisconsin–Madison · USVlaams Instituut voor Biotechnologie · BE
Funding
Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
NHLBI NIH HHS T32 HL007936
6 · The paper itself
Abstract
backgroundAdult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte proliferation is preceded by cardiomyocyte dedifferentiation (CMDD), wherein adult cardiomyocytes revert to a less matured state that is distinct from the classical myocardial fetal stress gene response associated with heart failure. However, very little is known about CMDD as a defined cardiomyocyte cell state in transition.
methodsHere, we leveraged 2 models of in vitro cultured adult mouse cardiomyocytes and in vivo adeno-associated virus serotype 9 cardiomyocyte-targeted delivery of reprogramming factors (
resultsRNA sequencing and integrated analysis identified
conclusionsWe discovered a novel gene
Indexed as
Aspartate-Ammonia LigaseCell DedifferentiationKruppel-Like Factor 4Myocytes, CardiacAnimalsCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCells, CulturedMiceAspartate-Ammonia LigaseCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4cell dedifferentiationcell self-renewalmyocytes, cardiacregeneration
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation. · full record | OpenQuestion