Evidence map›Paper›PMID 38586548›Full record

ArticleCurrent opinion in toxicology2024

Inter- and trans-generational impacts of environmental exposures on the germline resolved at the single-cell level.

Dylan Hatai, Max T Levenson, Virender K Rehan, Patrick Allard

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current opinion in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Germ cells and the aging niche: a systems approach to reproductive longevity.Journal of assisted reproduction and genetics · 2025
    Review
  2. Caenorhabditis Elegans as a Model for Environmental Epigenetics.Current environmental health reports · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dylan HataiUCLA Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Max T LevensonUCLA Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Virender K RehanUCLA Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Patrick AllardUCLA Molecular Toxicology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Training in Molecular ToxicologyT32ES015457 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALLARD, PATRICK, HANKINSON, OLIVER NMN · 2008 to 2025
$4.0M
E-Cigarette Vaping during Pregnancy and Lactation, Germ Cell Epigenetic Memory, and Transgenerational AsthmaR01HL151769 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ALLARD, PATRICK, REHAN, VIRENDER K · 2020 to 2023
$2.3M
Mechanisms of memory of environmental exposure: determining the role of histone modifications in regulating transgenerational behavior effects caused by environmental chemical exposure.R01ES027487 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALLARD, PATRICK · 2017 to 2021
$1.8M
Epigenetic and metabolic mechanisms of environmentally-induced transgenerational germline dysfunctionR01AA030160 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Patrick Allard · 2023 to 2026
$1.4M
Germ Cell-Mediated Epigenetic Memory of Ethanol ExposureR21AA024889 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALLARD, PATRICK · 2017 to 2018
$399k
NHLBI NIH HHS R01 HL151769NIAAA NIH HHS R01 AA030160NIAAA NIH HHS R21 AA024889NIEHS NIH HHS R01 ES027487NIEHS NIH HHS T32 ES015457
6 · The paper itself

Abstract

Reproduction is a remarkably intricate process involving the interaction of multiple cell types and organ systems unfolding over long periods of time and that culminates with the production of gametes. The initiation of germ cell development takes place during embryogenesis but only completes decades later in humans. The complexity inherent to reproduction and its study has long hampered our ability to decipher how environmental agents disrupt this process. Single-cell approaches provide an opportunity for a deeper understanding of the action of toxicants on germline function and analyze how the response to their exposure is differentially distributed across tissues and cell types. In addition to single-cell RNA sequencing, other single-cell or nucleus level approaches such as ATAC-sequencing and multi-omics have expanded the strategies that can be implemented in reproductive toxicological studies to include epigenomic and the nuclear transcriptomic data. Here we will discuss the current state of single-cell technologies and how they can best be utilized to advance reproductive toxicological studies. We will then discuss case studies in two model organisms (

Indexed as

C. eleganse-cigaretteethanolgermlinereproductionsinge cellsingle nucleus

Identifiers

PMID38586548
PMCPMC10993723
OpenAlexW4391651399

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.