ArticleJTO clinical and research reports2024
Improving Lung Cancer Screening Selection: The HUNT Lung Cancer Risk Model for Ever-Smokers Versus the NELSON and 2021 United States Preventive Services Task Force Criteria in the Cohort of Norway: A Population-Based Prospective Study.
Article in JTO clinical and research reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of lung cancer risk prediction models.Acta oncologica (Stockholm, Sweden) · 2025Pooled it
- Ever-smokers in Norway and lung cancer: median time from self-reported smoking debut to lung cancer diagnosis in 11 prospective population studies (CONOR).ERJ open research · 2026Article
- Feasibility of lung cancer screening in low-risk populations of the Nordic countries.Acta oncologica (Stockholm, Sweden) · 2026Article
- Baseline results from the Norwegian radiology-led lung cancer screening pilot.Acta oncologica (Stockholm, Sweden) · 2026Article
- Lung cancer screening in transition: highlights from the 3rd Oslo Lung Cancer Symposium, 2025.European clinical respiratory journal · 2026Article
- The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models.Journal of cancer research and clinical oncology · 2024Article
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6 authors.
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Abstract
Background: Improving the method for selecting participants for lung cancer (LC) screening is an urgent need. Here, we compared the performance of the Helseundersøkelsen i Nord-Trøndelag (HUNT) Lung Cancer Model (HUNT LCM) versus the Dutch-Belgian lung cancer screening trial (Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON)) and 2021 United States Preventive Services Task Force (USPSTF) criteria regarding LC risk prediction and efficiency. Methods: We used linked data from 10 Norwegian prospective population-based cohorts, Cohort of Norway. The study included 44,831 ever-smokers, of which 686 (1.5%) patients developed LC; the median follow-up time was 11.6 years (0.01-20.8 years). Results: Within 6 years, 222 (0.5%) individuals developed LC. The NELSON and 2021 USPSTF criteria predicted 37.4% and 59.5% of the LC cases, respectively. By considering the same number of individuals as the NELSON and 2021 USPSTF criteria selected, the HUNT LCM increased the LC prediction rate by 41.0% and 12.1%, respectively. The HUNT LCM significantly increased sensitivity ( Conclusions: The HUNT LCM was significantly more efficient than the NELSON and 2021 USPSTF criteria, improving the prediction of LC diagnosis, and may be used as a validated clinical tool for screening selection.
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