Evidence map›Paper›PMID 38586157›Full record

ArticleInternational journal of women's dermatology2024

A meta-analysis of the incidence of acne vulgaris in patients treated with GLP-1 agonists.

Oluwafunke O Ogunremi, Sana F Ismail, Ramneek K Dhami, Jazmin S Newton, Scott A Kindle, Valeriy Kozmenko

Abstract read
In one paragraph

Article in International journal of women's dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oluwafunke O OgunremiDepartment of Internal Medicine, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota.
Sana F IsmailKansas City University College of Osteopathic Medicine, Kansas City, Missouri.
Ramneek K DhamiUniversity of Nevada, Reno School of Medicine, Reno, Nevada.
Jazmin S NewtonDepartment of Internal Medicine, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota.
Scott A KindleDepartment of Internal Medicine, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota.
Valeriy KozmenkoDepartment of Internal Medicine, University of South Dakota Sanford School of Medicine, Vermillion, South Dakota.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: With the emerging popularity of GLP-1 receptor agonists, patients are noticing acne vulgaris side effects that are seemingly related to the concurrent treatment with the drug. Due to the correspondence between these drugs' relatively recent emergence in the U.S. market and their high demand, it is important to investigate what is currently known in the literature so that patients can be properly informed. Objective: The aim of this study is to investigate the relationship, or lack thereof, between glucagon like peptide 1 (GLP-1) receptor agonist usage and acne-related side effects in patients. Methods: A web-based analysis of 6 GLP-1 receptor agonists (3 with a once-weekly dosing schedule, and 3 with a once-daily dosing schedule) was conducted on PubMed online database. Boolean criteria were used to narrow the search. Included in the meta-analysis were 45 research articles that fulfilled the search criteria. Results: The results of the search showed that from the following long-acting GLP-1 receptor agonists, dulaglutide, exenatide extended release, and semaglutide (Wegovy), no conclusive acne side effects were reported. In addition, the results also showed that from the following short-acting GLP-1 receptor agonists, liraglutide, lixisenatide, and semaglutide (Rybelsus), no conclusive acne side effects were reported. Limitations: Limitations of this study include a limited amount of literature regarding the relationship between GLP-1 agonists and acne vulgaris. Conclusion: It is unlikely that GLP-1 agonists themselves are directly responsible for the acne that some patients may develop during treatment. Rather, it is more probable that the weight loss yielded by treatment with these drugs may induce intrinsic physiologic and hormonal changes that induce or exacerbate acne vulgaris in such patients.

Indexed as

acne vulgarisGLP-1 agonistsglucagon-like-peptide-1 receptor agonistsliraglutideOzempicsemaglutide

Identifiers

PMID38586157
PMCPMC10997314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.