Evidence map›Paper›PMID 38586043›Full record

ArticlebioRxiv : the preprint server for biology2024

GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea.

Julia L Bachman, Siân R Kitcher, Lucas G Vattino, Holly J Beaulac, M Grace Chaves, Israel Hernandez Rivera, Eleonora Katz, Carolina Wedemeyer, Catherine J C Weisz

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Julia L BachmanThese authors contributed equally.ORCID 0009-0005-3675-9793
Siân R KitcherThese authors contributed equally.ORCID 0000-0002-1881-5430
Lucas G VattinoInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428 Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0001-6340-844X
Holly J BeaulacSection on Neuronal Circuitry, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.ORCID 0000-0002-8168-0444
M Grace ChavesSection on Neuronal Circuitry, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.ORCID 0000-0002-2552-4279
Israel Hernandez RiveraSection on Neuronal Circuitry, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.
Eleonora KatzInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428 Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0002-5114-2899
Carolina WedemeyerInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, Dr. Héctor N. Torres, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428 Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0003-1757-5778
Catherine J C WeiszSection on Neuronal Circuitry, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.ORCID 0000-0002-2595-835X
National Institutes of Health · USMassachusetts Eye and Ear Infirmary · USExperimental Medicine and Biology Institute · ARUniversidad de Buenos Aires · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cochlear outer hair cells (OHCs) are electromotile and are implicated in mechanisms of amplification of responses to sound that enhance sound sensitivity and frequency tuning. They send information to the brain through glutamatergic synapses onto a small subpopulation of neurons of the ascending auditory nerve, the type II spiral ganglion neurons (SGNs). The OHC synapses onto type II SGNs are sparse and weak, suggesting that type II SGNs respond primarily to loud and possibly damaging levels of sound. OHCs also receive innervation from the brain through the medial olivocochlear (MOC) efferent neurons. MOC neurons are cholinergic yet exert an inhibitory effect on auditory function as they are coupled to alpha9/alpha10 nicotinic acetylcholine receptors (nAChRs) on OHCs, which leads to calcium influx that gates SK potassium channels. The net hyperpolarization exerted by this efferent synapse reduces OHC activity-evoked electromotility and is implicated in cochlear gain control, protection against acoustic trauma, and attention. MOC neurons also label for markers of gamma-aminobutyric acid (GABA) and GABA synthesis. GABA

Indexed as

afferentauditoryefferentGamma-Aminobutyric acid (GABA)medial olivocochlear (MOC)spiral ganglion neuron (SGN)synapse

Identifiers

PMID38586043
PMCPMC10996694
OpenAlexW4393357693

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.