Evidence map›Paper›PMID 38586019›Full record

ArticlebioRxiv : the preprint server for biology2024

An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking.

Yao Wang, Danyang Li, Joseph Widjaja, Rong Guo, Li Cai, Rongzhen Yan, Sahin Ozsoy, Giancarlo Allocca, Jidong Fang, Yan Dong and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Yao WangDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.
Danyang LiDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.
Joseph WidjajaNorth Allegheny High School, Pittsburgh, PA 15237.
Rong GuoDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.
Li CaiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.
Rongzhen YanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.
Sahin OzsoySomnivore Pty. Ltd., Bacchus Marsh, VIC, Australia 3340.
Giancarlo AlloccaSomnivore Pty. Ltd., Bacchus Marsh, VIC, Australia 3340.
Jidong FangDepartment of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA 17033.
Yan DongDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.
George C TsengDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.ORCID 0000-0002-5447-1014
Chengcheng HuangDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.
Yanhua H HuangDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219; 15260; 15213.ORCID 0000-0003-1770-0196
University of Pittsburgh · USAllegheny College · USIP Australia · AUPennsylvania State University · USThe University of Melbourne · AU

Funding

Subject Management and BiobankingP50DA046346 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, Colleen A McClung · 2020 to 2026
$23.4M
Glial-mediated synaptic remodeling in drug addictionR01DA040620 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong, ERIC J. NESTLER · 2016 to 2026
$5.3M
Cocaine-induced adaptation in NMDA receptorsR37DA023206 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong · 2018 to 2026
$3.9M
Topological bridges between circuits, models, and behaviorRF1NS121913 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COHEN, MARLENE ROCHELLE, MORRISON, JOHN H · 2021 to 2022
$3.2M
Cocaine-induced Adaptation in NMDA Receptors in Nucleus AccumbensR01DA023206 · NIDA · WASHINGTON STATE UNIVERSITY · PI DONG, YAN · 2008 to 2017
$3.0M
Mechanistic studies of alcohol-sleep interactionsR01AA028145 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YANHUA H, TORREGROSSA, MARY M · 2019 to 2023
$2.0M
Topological bridges between circuits, models, and behaviorR01NS121913 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COHEN, MARLENE ROCHELLE, HUANG, CHENGCHENG · 2024 to 2025
$1.9M
Sleep regulates drug relapse and addictionR01DA046491 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YANHUA H · 2019 to 2023
$1.8M
Developing a sleep EEG-based biomarker for drug relapse propensityR01DA057954 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yanhua H Huang · 2024 to 2026
$1.6M
Interaction of Glutamatergic Inputs to Nucleus AccumbensR21DA051010 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONG, YAN · 2020 to 2021
$431k
Circuitry Progression of Cocaine-induced Cellular AdaptationR21DA047861 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONG, YAN · 2019 to 2020
$430k
REM Sleep in Cocaine RelapseR21DA043826 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YANHUA H · 2018 to 2019
$430k
NIAAA NIH HHS R01 AA028145NIDA NIH HHS P50 DA046346NIDA NIH HHS R01 DA023206NIDA NIH HHS R01 DA040620NIDA NIH HHS R01 DA046491NIDA NIH HHS R01 DA057954NIDA NIH HHS R21 DA043826NIDA NIH HHS R21 DA047861NIDA NIH HHS R21 DA051010NIDA NIH HHS R37 DA023206NINDS NIH HHS R01 NS121913NINDS NIH HHS RF1 NS121913
6 · The paper itself

Abstract

Background: Identifying biomarkers that predict substance use disorder (SUD) propensity may better strategize anti-addiction treatment. The melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) critically mediates interactions between sleep and substance use; however, their activities are largely obscured in surface electroencephalogram (EEG) measures, hindering the development of biomarkers. Methods: Surface EEG signals and real-time Ca Results: An EEG waveform derivative - a modified theta-to-delta ratio (EEG Ratio) - accurately tracks real-time Ca Conclusions: The identified EEG Ratio may serve as a non-invasive measure for assessing MCH neuron activities

Indexed as

biomarkercocaineEEGMCHREM sleep

Identifiers

PMID38586019
PMCPMC10996698
OpenAlexW4393302079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.